Hb、MCV、MCH在腾冲汉族地贫筛查中的临床应用价值

Clinical application value of Hb,MCV and MCH in thalassemia screening in Han ethnicity at Tengchong

目的探讨血液学参数血红蛋白浓度(Hb)、平均红细胞体积(MCV)、红细胞平均血红蛋白含量(MCH)在腾冲市汉族人群缺失型α-地中海贫血和常见突变型β-地中海贫血筛查中的临床应用价值,研究临床初筛方案。方法随机选择2017年12月在腾冲市人民医院检验科进行常规体检的500例汉族受试者进行血常规检测,通过基因诊断确诊为常见的缺失型α-地中海贫血和突变型β-地中海贫血,比较Hb、MCV、MCH单项及联合检测对地中海贫血筛查的灵敏度和特异度,探讨其临床应用价值,制定适合当地人群的临床筛查截断值。结果腾冲市汉族中最常见的α-和β-地中海贫血分别为-α3.7/αα和异常血红蛋白E(HbE),血液学参数MCH、MCV分别为筛查-α3.7/αα及HbE筛查最具价值的指标。结论血液学参数Hb、MCV、MCH对腾冲市汉族人群上述2种常见地中海贫血的筛查有临床应用价值。

Objective To explore the clinical effects of hematological characteristics of hemoglobin concentration (Hb),mean corpuscular volume (MCV),and mean corpuscular hemoglobin content (MCH) in screening common deletional α-thalassemia and mutant β-thalassemia in Han ethnicity at Tengchong and study the clinical screening projects. Methods A total of 500 subjects of Han ethnicity who underwent routine physical examination in the Department of Clinical Laboratory of the People′s Hospital of Tengchong in December 2017 were randomly selected for routine blood test,and the common deleted alpha-thalassemia and mutant beta-thalassemia were diagnosed by gene diagnosis.The sensitivity and specificity of Hb,MCV and MCH for screening thalassemia were compared in order to explore its clinical application value and to establish the cut-off value of clinical screening suitable for local population. Results The common genotype of α-thalassemia and β-thalassemia in Han ethnicity in Tengchong city were-α 3.7 /αα and abnormal hemoglobin E (HbE) respectively.MCH and MCV analysis were the most valuable indicators for screening-α 3.7 /αα and HbE respectively. Conclusion Hematological characteristics of Hb,MCV and MCH have application value for screening common deletional α-thalassemia and mutant β-thalassemia in Han ethnicity at Tengchong.