血清PTA、FIB水平在进展性脑梗死病情评价中的临床意义

Analysis of the clinical significance of serum PTA and FIB level in evaluating progressive cerebral infarction

目的分析血清凝血酶原活动度(PTA)、纤维蛋白原(FIB)水平在进展型脑梗死病情评价中的临床意义,为脑梗死早期监测及评估提供参考意见。方法采用病例抽样法抽取于2017年1-12月收治的经临床诊断为脑梗死的患者,按照纳入标准共纳入患者113例,其中轻症组59例,重症组54例;通过临床症状评分及生活质量评分对患者的病情严重度进行评分;采用start4半自动血凝分析仪进行血清PTA的检测;采用酶联免疫吸附法(ELISA)检测患者血清FIB水平。结果两组患者之间血清PTA、FIB水平的差异均有统计学意义(P<0.05);PTA(%)及FIB(g/L)与脑卒中患者主观症状评分、脑神经症状评分、躯体症状评分、认知功能评分、情绪功能评分、社会功能评分均呈负相关(P<0.05);所有组合方式下得到的灵敏度、特异度均不低于60%。结论血清PTA、FIB水平检测对预测脑卒中预后状况患者的严重程度均有一定的诊断价值。血清PTA及FIB水平的升高提示进展型脑梗死病情严重,可将其作为脑卒中患者早期的常规检测指标。

Objective To analyze the clinical significance of serum prothrombin activity (PTA) and fibrinogen (FIB) level in the evaluation of progressive cerebral infarction,and to provide reference for early monitoring and evaluation of cerebral infarction. Methods Patients with clinically diagnosed cerebral infarction were enrolled from January to December in 2017 by case sampling method.A total of 113 patients were enrolled according to the inclusion criteria,including 59 patients in the mild group and 54 patients in the severe group.The severity of the patients was scored by clinical symptom score and quality of life score.The semi-automated hemagglutination analysis was performed using start4.The instrument was tested for serum PTA,serum FIB levels were measured by enzyme-linked immunosorbent assay (ELISA). Results There were significant differences in serum PTA and FIB level between the two groups (P<0.05).PTA and FIB were negatively correlated to subjective symptom score,cranial nerve symptom score,somatic symptom score,cognitive function score,emotional function score,and social function score of stroke patients (P<0.05).The sensitivity and specificity obtained under all combinations were not less than 60%. Conclusion PTA and FIB level detection have certain diagnostic value for predicting the severity of stroke prognosis patients.The increase of serum PTA and FIB level indicates that the progressive cerebral infarction is serious,which can be used as an early routine indicator for stroke patients.