靶向治疗联合化疗在脑肿瘤患者中的应用效果

Application effect of targeted therapy combined with chemotherapy in patients with brain tumors

目的探讨靶向治疗联合化疗在脑肿瘤患者中的临床治疗效果。方法选取2016年10月~2018年10月我院收治的50例脑肿瘤患者为研究对象,随机将其分为观察组(n=25)和对照组(n=25),观察组给予靶向治疗联合化疗治疗,对照组仅给予化疗治疗。对比两组患者的治疗总有效率、生活质量改善情况以及不良反应发生情况。结果观察组的临床治疗有效率为72.0%,明显高于对照组的44.0%(P<0.05);观察组的生活质量改善率为76.0%,明显高于对照组的48.0%(P<0.05);观察组的口腔炎、恶心呕吐、脱发、贫血、白细胞减少、血小板减少、肝功能异常的发生率明显明显低于对照组(P<0.05)。结论脑肿瘤患者采用靶向治疗联合化疗的治疗方式具有显著的疗效,而且可以降低不良反应发生率,安全性高,值得大力推广。

Objective To investigate the clinical therapeutic effect of targeted therapy combined with chemotherapy in patients with brain tumors. Methods Fifty patients with brain tumors admitted in our hospital from October 2016 to October 2018 were enrolled in the study. They were randomly divided into observation group(n=25) and control group(n=25). The observation group was given targeted therapy combined with chemotherapy, and the control group was given only chemotherapy. The total effective rate of treatment, quality of life improvement and adverse reactions were compared between the two groups. Results The clinical effective rate of the observation group was 72.0%, which was significantly higher than that of the control group(44.0%)(P<0.05). The improvement rate of quality of life in the observation group was 76.0%, which was significantly higher than that of the control group(48.0%)(P<0.05). The incidence of stomatitis, nausea and vomiting, alopecia, anemia, leukopenia, thrombocytopenia, and abnormal liver function in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Targeted therapy combined with chemotherapy in the treatment of brain tumor patients has significant curative effect, and can reduce the incidence of adverse reactions, with high safety, which is worthy of promotion.