经皮肾镜碎石术治疗复杂性肾结石的临床疗效及对患者肾功能的影响

Clinical efficacy of percutaneous nephrolithotripsy in the treatment of complex renal calculi and its effects on renal function

目的:探究经皮肾镜碎石术治疗复杂性肾结石的临床疗效及对患者肾功能的影响。方法:选取200例复杂性肾结石患者作为研究对象,分为对照组和观察组,每组各100例。对照组采用传统开放性取石术,观察组采用经皮肾镜碎石术,比较两组手术指标(手术时间、术中出血量)、恢复指标(下床活动时间、住院时间)、疗效指标(结石清除率、并发症发生率)以及肾功能指标(血尿素氮BUN、血肌酐Scr)。结果:观察组手术时间、术中出血量、术后下床活动时间和住院时间均优于对照组,差异有统计学意义(P<0.05)。观察组结石清除率为95.00%(95/100),并发症发生率为4.00%(4/100),对照组结石清除率为86.00%(86/100),并发症发生率为12.0%(12/100),两组差异有统计学意义(P<0.05)。术前,两组BUN、Scr水平差异无统计学意义(P>0.05);术后,观察组BUN、Scr水平低于对照组,差异有统计学意义(P<0.05)。结论:经皮肾镜碎石术应用在复杂性肾结石的治疗中疗效显著,对患者造成的创伤小,术后恢复快,安全性高,可以促进肾功能的改善。

Objective: To investigate the clinical efficacy of percutaneous nephrolithotripsy in the treatment of complex renal calculi and its effects on renal function. Methods: 200 patients with complex renal calculi in our hospital were selected as the subjects, and they were divided into the control group and observation group with 100 cases in each group. Patients in the control group received conventional open lithotomy, while patients in the observation group recieved percutaneous nephroscope lithotripsy. Then the operation indicators(operation time and intraoperative blood loss), recovery indexes(activity time and hospital stay), curative effect indexes(stone clearance rate, postoperative complications)and renal indexes(blood urea nitrogen(BUN)and serum creatinine(Scr))of patients were compared between both groups. Results: The operation time, intraoperative blood loss, postoperative activity time and hospital stay of patients in the observation group were all better than those in the control group, which were of statistical differences(P<0.05). The stone clearance rate of the observation group and control group was 95.00% and 86.00%, the complication rate was 4.00% and 12.0% respectively, which were of statistical differences between both groups(P<0.05). Before surgery, there was no statistically significant difference of BUN and Scr levels in patients between the two groups(P>0.05). But after surgery, levels of BUN and Scr of patients in the observation group were lower than those in the control group, which were of statistical differences(P<0.05). Conclusion: The application of percutaneous nephrolithotripsy in the treatment of complex renal calculi has significant curative effect for patients with less trauma, rapid postoperative recovery, high safety, and it can promote the improvement of the patients’ renal functions.