有核梭状杆菌与结直肠癌发病关系研究进展

Research progress of the correoation of colorectal cancer and fusobacterium nucleatum infection

结直肠癌(CRC)是人体最常见恶性肿瘤之一,早期诊断和早期治疗是提高肿瘤患者生存率的重点和难点。有核梭状杆菌(FN)是寄生于人体口腔的主要厌氧致病菌,与多种牙周疾病和其他疾病发生高度相关。近年来,对FN和CRC发生之间的关系和FN导致CRC的机制研究是国内外肿瘤学研究热点之一,同时也取得了一定的进展。笔者就FN导致CRC发生的相关性研究的最新进展进行综述。

Colorectal cancer(CRC)is one of the most common human malignant tumor, and the earlier diagnosis and treatment of CRC is critical and also difficult to increase survival rate of CRC patients. Fusobacterium nucleatum(FN)is the major anaerobic pathogens parasitizing human oral cavity, and it may causes various kinds of periodontal diseases and other diseases. In recent years, the research on the relationship between FN and CRC occurrence and the mechanism of FN leading to CRC is one of the hotspots in oncology research at home and abroad, in which certain progresses have already been made. Here, we review the latest correlated research progress between FN resulting and CRC.