药物超敏反应综合征

Drug-induced hypersensitivity syndrome

药物超敏反应综合征又称药疹伴嗜酸性粒细胞增多及系统症状,是一种罕见且严重的药物不良反应,临床表现为皮疹、血液系统异常、淋巴结病及内脏系统受累(肝、肾、肺等)。其发病机制目前尚不明确,与多种因素有关,包括药物特异性免疫反应、病毒感染再激活及遗传等。停用可疑药物是治疗的关键,皮质类固醇、静脉注射免疫球蛋白的使用仍有争议。

Drug-induced hypersensitivity syndrome is also known as drug reaction with eosinophilia and systemic symptoms which is a rare and serious adverse drug reaction.The clinical manifestations include skin eruption, hematologic abnormalities, lymphadenopathy, and internal organ involvement (liver, kidney, lung). Its pathogenesis is still unclear and is considered to be related to a variety of factors, including drug-specific immune responses, viral reactivation and inheritance.Prompt withdrawal of suspicious drugs is the key to treatment, and the use of systemic corticosteroids and intravenous immunoglobulins remains controversial.