5%碳酸氢钠耳浴联合制霉菌素粉治疗真菌性外耳道炎的疗效观察

Clinical observation of 5% sodium bicarbonate ear bath combined with nystatinum powder in treatment of fungal otitis externa

目的探讨5%碳酸氢钠注射液耳浴联合制霉菌素片粉治疗真菌性外耳道炎临床疗效。方法选取2016年8月—2018年4月于秦皇岛市中医医院治疗的真菌性外耳道炎患者213例作为研究对象,将患者按随机数表法分为对照组(75例)和治疗组(138例)。对照组患者给予制霉菌素片,用研钵磨成极细粉末后,用喷壶吹入外耳道内,1次/d。治疗组采用5%碳酸氢钠注射液,耳浴15 min,1次/d,用生理盐水冲洗擦干,然后按照对照组操作。两组患者均治疗10 d。观察两组患者的临床疗效,并比较两组的真菌转阴率。结果治疗后,治疗组总有效率为90.6%,显著高于对照组的77.3%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者真菌转阴率为83.3%,显著高于对照组的66.7%,两组比较差异有统计学意义(P<0.05)。结论 5%碳酸氢钠注射液耳浴联合制霉菌素片治疗真菌性外耳道炎具有较好的临床疗效,真菌转阴率高,不良反应小,具有一定的临床推广应用价值。

Objective To investigate the curative effect of 5% Sodium Bicarbonate Injection ear bath combined with Nystatinum Tablets in treatment of fungal otitis externa.Methods Patients (213 cases) with fungal otitis externa in Qinhuangdao City Hospital of Chinese Medicine Hospital from August 2016 to April 2018 were divided into control (75 cases) and treatment (138 cases) groups according to the random number table method.Patients in the control group were given Nystatinum Tablets,grinded into powder with a mortar,injected into the external auditory with a spray pot,once daily.Patients in the treatment group were treated with 5% Sodium Bicarbonate Injection ear bath for 15 min,once daily,washed and dried with normal saline,and then operated according to the control group.Patients in two groups were treated for 10 d.After treatment,the clinical efficacy was evaluated,and the fungal negative conversion rate in two groups was compared.Results After treatment,the clinical efficacy in the treatment group was 90.6%,which was higher than 77.3% in the control group,and there were differences between two groups (P < 0.05).After treatment,fungal negative conversion rate in the treatment group was 83.3%,which was significantly higher than 66.7% in the control group,and there were differences between two groups (P < 0.05).Conclusion 5% Sodium Bicarbonate Injection ear bath combined with Nystatinum Tablets has good clinical efficacy in treatment of fungal otitis externa,and it has high fungal negative conversion rate and low adverse reactions,which has a certain clinical application value.