骨康胶囊联合洛索洛芬钠治疗膝关节骨性关节炎的临床研究

Clinical study on Gukang Capsules combined with loxoprofen sodium in treatment of knee osteoarthritis

目的观察骨康胶囊联合洛索洛芬钠片治疗膝关节骨性关节炎的临床疗效。方法选取2016年11月—2018年7月荆州市中医医院收治的142例膝关节骨性关节炎患者作为研究对象,采用双盲法将所有患者随机分为对照组和治疗组,每组各71例。对照组口服洛索洛芬钠片,60mg/次,3次/d。治疗组在对照组的基础上口服用骨康胶囊,3粒/次,3次/d。两组患者均持续治疗1个月。观察两组患者的临床疗效,比较两组治疗前后的Lysholm膝关节评分、骨关节指数评分(WOMAC)、视觉模拟评分(VAS)和血清学指标。结果治疗后,对照组和治疗组的临床有效率分别为84.51%、92.95%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组Lysholm评分显著升高,WOMAC、VAS评分显著降低(P<0.05);治疗后,治疗组上述评分均显著优于对照组(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)水平明显降低,转化生长因子-β1(TGF-β1)水平明显升高(P<0.05);治疗后,治疗组血清学指标明显优于对照组(P<0.05)。结论骨康胶囊联合洛索洛芬钠片治疗膝关节骨性关节炎疗效确切,可减轻患者疼痛和炎症因子水平,改善关节活动度,具有较好的临床推广应用价值。

Objective To observe the clinical effect of Gukang Capsules combined with Loxoprofen Sodium Tablets in treatment of knee osteoarthritis.Methods Patients (142 cases) with knee osteoarthritis in Jingzhou Hospital of Traditional Chinese Medicine from November 2016 to July 2018 were randomly divided into control and treatment groups by double-blind method,and each group had 71 cases.Patients in the control group were po administered with Loxoprofen Sodium Tablets,60 mg/time,three times daily.Patients in the treatment group were po administered with Gukang Capsules on the basis of control group,3 grains/time,three times daily.Patients in two groups were treated for 1 month.After treatment,the clinical efficacy was evaluated,and the Lysholm scores,WOMAC scores,VAS scores,and serological indexes in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control and treatment groups was 84.51% and 92.95%,respectively,and there were differences between two groups (P < 0.05).After treatment,the Lysholm scores in two groups were significantly increased,but WOMAC scores and VAS scores were significantly decreased (P< 0.05).After treatment,and these scores in the treatment group were significantly better than those in the control group (P< 0.05).After treatment,the levels of TNF-α and VEGF in two groups were significantly decreased,but TGF-β1 were significantly increased (P< 0.05).After treatment,serological indexes in the treatment group were significantly better than those in the control group (P< 0.05).Conclusion Gukang Capsules combined with Loxoprofen Sodium Tablets has a definite effect in treatment of knee osteoarthritis,can alleviate pain and reduce the inflammatory factor levels,and improve the range of motion of the joint,which has a certain clinical application value.