三金片联合复方磺胺甲?唑治疗急性肾盂肾炎的临床研究

Clinical study on Sanjin Tablets combined with compound sulfamethoxazole in treatment of acute pyelonephritis

目的探讨三金片联合复方磺胺甲唑治疗急性肾盂肾炎的临床疗效。方法选取2015年3月—2018年3月唐山市丰润区中医医院收治的106例急性肾盂肾炎患者,随机分成对照组和治疗组,每组各53例。对照组口服复方磺胺甲唑片,2片/次,2次/d。治疗组在对照组治疗基础上口服三金片,3片/次,3次/d。两组均连续治疗14d。观察两组的临床疗效和两组临床症状消失时间,比较两组治疗前后尿常规指标、血常规指标和血清学指标的变化情况。结果治疗后,对照组和治疗组的总有效率分别是81.1%、94.3%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组寒战消失时间、发热消失时间、腰痛消失时间、尿路刺激征消失时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组尿白细胞(WBC)、尿红细胞(RBC)数、血WBC数及血中性粒细胞百分比(NEU%)均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组尿WBC数、尿RBC数、血WBC数及血NEU%显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清白介素(IL)-8、C反应蛋白(CRP)、降钙素原(PCT)水平较治疗前均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组IL-8、CRP、PCT均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论三金片联合复方磺胺甲唑治疗急性肾盂肾炎具有较好的临床疗效,可缩短患者临床症状消失时间,控制细菌感染,减轻机体炎性损伤,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Sanjin Tablets combined with compound sulfamethoxazole in treatment of acute pyelonephritis.Methods Patients (106 cases) with acute pyelonephritis in Fengrun District Hospital of Traditional Chinese Medicine in Tangshan from March 2015 to March 2018 were randomly divided into control (53 cases) and treatment (53 cases) groups.Patients in the control group were po administered with Compound Sulfamethoxazole Tablets,2 tablets/time,twice daily.Patients in the treatment group were po administered with Sanjin Tablets on the basis of the control group,3 tablets/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy and disappearance time of clinical symptoms were evaluated,and changes of urine routine indexes,blood routine indexes and serological indexes in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control and treatment groups were 81.1% and 94.3%,respectively,and there were differences between two groups (P < 0.05).After treatment,the disappearance time of chills,fever,lumbago and urinary tract irritation in the treatment group was significantly shorter than that in the control group,and there were differences between two groups (P < 0.05).After treatment,the number of WBC and RBC of urine,WBC and NEU% of blood in both groups were significantly lower than that before treatment,and there were differences in the same group (P < 0.05).After treatment,the number of WBC and RBC of urine,WBC and NEU% of blood in the treatment group were lower than those in the control group,and there were differences between two groups (P < 0.05).After treatment,IL-8,CRP,and PCT in both groups were significantly lower than that before treatment,and there were differences in the same group (P < 0.05).After treatment,IL-8,CRP,and PCT in the treatment group were lower than those in the control group,and there were differences between two groups (P < 0.05).Conclusion Sanjin Tablets combined with compound sulfamethoxazole has significant effect in treatment of acute pyelonephritis,and can shorten the disappearance time of clinical symptoms,and can control bacterial infection and reduce inflammatory injury of the body,which has a certain clinical application value.