不同人群的肺炎支原体总抗体及免疫球蛋白M抗体检测结果分析

Analysis of the total antibody and immunoglobulin M antibody of mycoplasma pneumoniae in patients with respiratory infection of adults children and perinatal pregnant women

目的分析成人、儿童及围产期孕妇的呼吸道感染患者肺炎支原体总抗体及免疫球蛋白(Ig)M抗体阳性检出情况,探讨呼吸道感染患者感染肺炎支原体的流行趋势,为临床治疗和预防提供依据。方法采集呼吸道感染患者的血清,间接免疫法(IFA)检测肺炎支原体IgM抗体及被动凝集法检测肺炎支原体总抗体(IgM,IgG和IgA),分析它们在呼吸道感染性疾病中的检出情况及临床意义。按照成人、儿童及围产期孕妇进行分组比较。结果8 482例呼吸道感染患者肺炎支原体IgM抗体阳性检出率为32.92%;肺炎支原体总抗体阳性检出率为43.99%;其中成人组肺炎支原体IgM抗体及总抗体阳性检出率分别为28.76%和43.46%;儿童组肺炎支原体IgM抗体及总抗体阳性检出率分别为47.04%和42.97%;围产期孕妇组肺炎支原体IgM抗体及总抗体阳性检出率分别为48.75%和62.37%;儿童组、围产期孕妇组与成人组之间阳性检出率差异有统计学意义(P<0.05),围产期孕妇组阳性检出率最高,儿童组次之。结论肺炎支原体是引起呼吸道感染的最主要病原体,感染在成人组、儿童组和围产期孕妇组之间存在差异,围产期孕妇组阳性检出率最高,儿童组次之,应重点防治。

Objective To analyze the prevalence and the epidemic trend of Mycoplasma pneumoniae antibodies and immunoglobulin(Ig)M antibodies in adults,children and perinatal pregnant women with respiratory tract infections,so as to provide evidence for clinical treatment and prevention.Methods Serum from patients with respiratory tract infection was collected,indirect fluororescence assay(IFA)was used to detect IgM antibody of Mycoplasma pneumoniae and passive particle agglutination method was used to detect total Mycoplasma pneumoniae antibodies(IgM,IgG and IgA),and clinical significance of respiratory infectious diseases were analyzed.A group of adults,children and perinatal pregnant women were compared.Results Eight thousand four hundred and eighty-two cases of respiratory tract infections patients with mycoplasma pneumonia IgM antibody positive rate was 32.92%;the total mycoplasma pneumonia antibody positive rate was 43.99%;in the adult group,Mycoplasma pneumoniae IgM antibody and total antibody positive rates were respectively 28.76%and 43.46%;the group of children mycoplasma pneumonia IgM antibody and total antibody positive rates were respectively 47.04%and 42.97%;perinatal pregnancy group mycoplasma pneumonia IgM antibody and total antibody positive rates were 48.75%and 62.37%;the positive rate in the group of children,pregnant women and adult was statistically significant(P<0.05).The positive rate in pregnant women was the highest,followed by the children.Conclusion Mycoplasma pneumonia is the main pathogens of respiratory tract infection.The infection is a difference between the adult group,the children group and the perinatal pregnant group.The positive rate in pregnant women during was the highest,followed by the children,should be the focus of prevention and control.