司来吉兰与左旋多巴联用治疗帕金森病运动障碍的临床疗效分析

Clinical Efficacy Analysis of Combined Therapy of Selegilin and Levodopa in the Treatment of Parkinson’s Disease with Dyskinesia

目的:分析和研究对司来吉兰与左旋多巴联用治疗帕金森病运动障碍的临床治疗效果。方法:回顾了本院收治的84例帕金森运动障碍患者的治疗资料,采取双盲法将所有的研究患者分成对照(n=42)以及观察组(n=42)。对照组患者使用左旋多巴治疗,观察组在对照组治疗基础之上增加司来吉兰进行治疗。之后对比对照组和观察组两组患者的治疗效果以及UPDRS评分。结果:对照组患者治疗效、UPDRS评分明显差异观察组,组别之间差异存在统计学意义(P<0.05)。结论:在治疗患有帕金森病患者障碍的患者时,使用司来吉兰和左旋多巴的结合治疗方式具有显著效果,值得在医院内推广使用。

Objective:To study and analyze the clinical efficacy of selegiline combined with levodopa in the treatment of dyskinesia in Parkinson's disease.Methods:84 patients with Parkinson's disease dyskinesia were randomly divided into the control group(n=42)and the observation group(n=42).The control group was treated with levodopa.The observation group used selegiline and The combination treatment with levodopa was followed by the treatment effect and UPDRS scores of the control group and the observation group.Results:There were significant differences in the therapeutic efficacy and UPDRS scores between the control group and the control group.There was a statistically significant difference between the groups(P<0.05).Conclusion:In the treatment of patients with Parkinson's disease and dyskinesia,the combination of selegiline and levodopa has an ideal clinical effect and is worthy of promotion.