急诊创伤早期应用酒石酸布托啡诺镇痛临床效果观察

Clinical Study of Butorphanol in the Analgesia for Early Stage of Trauma

目的比较酒石酸布托啡诺与吗啡治疗急诊创伤性疼痛的临床疗效及安全性。方法选择2017年12月至2018年11月航天中心医院急诊收治的创伤早期患者100例作为研究对象,采用随机数字表法分为酒石酸布托啡诺组与吗啡组各50例,酒石酸布托啡诺组肌内注射酒石酸布托啡诺2mg,吗啡组肌内注射吗啡10mg。比较两组患者用药后生命体征变化、镇痛的效果和不良反应的发生情况。结果用药后30min,吗啡组呼吸和平均动脉压与酒石酸布托啡诺组比较,差异有显著性(P<0.05);用药后60min吗啡组动脉血氧饱和度与酒石酸布托啡诺组比较,差异有显著性(P<0.05);两组患者用药后15、30、45、60min的视觉模拟评分比较,差异无显著性(P>0.05);酒石酸布托啡诺组不良反应发生率为2%,吗啡组患者的不良反应发生率为8%,差异有显著性(P<0.05)。结论酒石酸布托啡诺不良反应少,镇痛效果好,是急诊创伤早期安全有效的镇痛药物。

Objective To compare the clinical efficacy and safety of butorphanol tartrate and morphine in the treatment of acute traumatic pain.Method From December 2017 to November 2018,100 patients with early trauma were randomly divided into butorphanol group(n=50)and morphine group(n=50).butorphanol group was treated with butorphanol tartrate 2 mg intramuscular injection and morphine group with morphine 10 mg intramuscular injection for analgesia.The changes of vital signs,analgesic effects and adverse reactions were compared between the two groups.Result There were significant differences in RR and MAP between morphine group and butorphanol group 30 minutes after administration,(P<0.05);And there were significant differences in Sp02 and butorphanol group 60 minutes after administration,(P<0.05).There was no statistical difference in VAS scores at 15,30,45 and 60 minutes after treatment,(P>0.05).The incidence of adverse reactions in butorphanol tartrate group was 2%,while in the morphine group it was 8%,the difference was significant(P<0.05).Conclusion Butorphanol tartrate has less adverse reactions and good analgesic effect.It is a safe and effective analgesic.