滋阴补阳方序贯法治疗日节律紊乱性排卵障碍的临床研究

Clinical Study on Daily Rhythmic Disorder Ovulation Failure Treated by Yin-nourishing and Yang-invigorating Prescription Sequential Method

目的:观察滋阴补阳方序贯法联合氯米芬(CC)、人绝经期促性腺激素(HMG)、人绒毛膜促性腺激素(HCG)治疗日节律紊乱性排卵障碍的临床疗效。方法:将日节律紊乱性排卵障碍患者80例根据不同治疗方案分为试验组40例,予滋阴及补阳方序贯法联合CC、HMG、HCG方案治疗,对照组40例予CC、HMG、HCG方案治疗。观察2组患者周期排卵率、单卵泡排卵率、卵泡输出率、卵巢过度刺激综合征(OHSS)发生率、注射HCG日子宫内膜厚度、未破裂黄素化综合征(LUFS)发生率及周期妊娠率、周期流产率、周期双胎妊娠率。结果:试验组患者卵泡输出率、注射HCG日内膜厚度以及周期妊娠率较对照组高,差异具有统计学意义(P<0.05);周期排卵率、单卵泡排卵率、LUFS发生率、OHSS发生率、周期流产率、周期双胎妊娠率2组比较差异无统计学意义(P>0.05)。结论:滋阴补阳序贯法联合CC、HMG、HCG治疗日节律紊乱性排卵障碍患者能升高患者卵泡输出率,增加子宫内膜厚度,改善子宫内膜容受性,提高妊娠率。

Objective: To observe clinical effects of Yin-nourishingand Yang-invigorating prescription sequential method combined with clomiphene(CC), human menopausal gonadotropin(HMG) and human chorionic gonadotropin (HCG) in the treatment for daily rhythmic disorder ovulation failure. Methods: According to different regimens, eighty patients were assigned to 40 cases of the experiment group, who were treated by Yin-nourishing and Yang-invigorating prescription sequential method combined with CC, HMG and HCG regimen, and 40 cases of the control group, who received CC, HMG and HCG regimen. To observe cycle ovulation rate, single follicle ovulation rate, follicular output rate, ovarian hyperstimulation syndrome(OHSS) rate, endometrial thickness at the day of injecting HCG, the incidence of luteinized unrupture follicle syndrome(LUFS), cycle pregnancy rate, cycle abortion rate and cycle twin pregnancy rate of both groups. Results: The experiment group was higher than the control group in follicular output rate, endometrial thickness at the day of injecting HCG and cycle pregnancy rate, and the difference had statistical meaning(P<0.05);No differences had been found in cycle ovulation rate, single follicle ovulation rate, LUFS incidence, OHSS incidence, cycle abortion rate and cycle twin pregnancy rate between both groups(P>0.05). Conclusion: Yin-nourishing Yang-invigorating prescription sequential method combined with CC, HMG and HCG could raise, follicular output rate, increase endometrial thickness, improve endometrial receptivity and pregnancy rate.