原发性高血压患者心率变异性及血压变异性与血管损害的相关性研究

Correlation between Heart Rate Variability and Blood Pressure Variability with Vascular Damage in Patients with Essential Hypertension

目的:探讨原发性高血压患者心率变异性(HRV)及血压变异性(BPV)与血管损害的相关性。方法:选取2014年12月到2017年12月期间在我院接受治疗的原发性高血压患者94例,根据脉搏波传导速度(PWV)的不同分为对照组(60例)和血管受损组(34例)。比较两组患者的HRV、BPV指标,并分析PWV与HRV、BPV指标的相关性。结果:血管受损组的5 min心搏R-R间期平均值的标准差(SDANN)低于对照组,低频(LF)、高频(HF)、低高频之比(LF/HF)高于对照组,差异均有统计学意义(P<0.05);血管受损组的24h平均收缩压(24h SBP)、24h平均脉压(24h PP)、白天平均收缩压(dSBP)、白天平均脉压(dPP)、夜间平均收缩压(nSBP)、夜间平均脉压(nPP)高于对照组,差异均有统计学意义(P<0.05);PWV与LF、HF、LF/HF、24h SBP、24h PP、dSBP、dPP、nSBP、nPP均呈正相关(P<0.05)。结论:原发性高血压患者部分HRV、BPV指标与PWV呈明显的相关性,说明HRV和BPV与患者的血管损害密切相关。

Objective: To investigate the correlation between heart rate variability(HRV) and blood pressure variability(BPV)with vascular damage in patients with essential hypertension. Methods: 94 patients with essential hypertension who were treated in our hospital from December 2014 to December 2017 were selected, and they were divided into control group(60 cases) and vascular damage group(34 cases) according to the difference of pulse wave velocity(PWV). The HRV and BPV indexes of the two groups were compared, and the correlation between PWV and HRV, BPV indexes was analyzed. Results: The standard deviation of the mean value of the 5 min heart beat R-R interval(SDANN) in the vascular damage group was lower than that of the control group, low frequency(LF),high frequency(HF) and the ratio of low frequency(LF/HF) was higher than that of the control group, and the difference was statistically significant(P<0.05). 24 h mean systolic blood pressure(24 h SBP),24 h the average pulse pressure(24 h PP), daytime average systolic blood pressure(d SBP), daytime average pulse pressure(dPP), nocturnal mean systolic blood pressure(n SBP), nocturnal average pulse pressure(nPP) in vascular damage group was higher than the control group, the differences were statistically significant(P <0.05). PWV was positively related to LF, HF, LF/HF, 24 h SBP, 24 h PP, dSBP, dPP, nSBP, nPP(P<0.05). Conclusion: The HRV and BPV indexes of patients with essential hypertension are significantly correlated with PWV, indicating that HRV and BPV are closely related to the vascular damage of the patients.