预消化的肠内营养对ICU危重症患者的营养状况及肠内营养耐受性的影响

Effect of Pre-digested Enteral Nutrition on the Nutritional Status and Enteral Nutrition Tolerance of Critically ill Patients in ICU

目的:研究预消化的肠内营养制剂对ICU危重症患者营养状况及肠内营养耐受性的影响。方法:本试验为前瞻、随机、对照、单盲研究,将符合入组条件的ICU患者随机分为试验组和对照组。试验组给予预消化型肠内营养制剂,而对照组给予整蛋白型肠内营养制剂进行营养支持。比较两组患者入组及营养支持2周后的营养指标、肠内营养耐受性及ICU住院天数等。结果:治疗2周后,试验组前白蛋白、转铁蛋白较对照组明显升高(P<0.05),肠内营养不耐受、腹内压升高、腹泻、肠鸣音减弱及胃肠道出血发生率较对照组明显降低(P<0.05),ICU住院时间也较对照组明显缩短(P<0.05)。结论:预消化的肠内营养制剂对ICU患者有良好的治疗效果,可降低胃肠道不良反应发生率,提高耐受性,明显改善患者营养状况。

Objective: To study the effect of pre-digestion enteral nutrition formula on the nutritional status and enteral nutrition tolerance in the critically ill patients in ICU. Methods: A prospective, randomized, controlled, and single blind study was performed. The ICU patients who met the conditions of admission were randomly divided into the experimental group and the control group. The experimental group was given pre-digestion enteral nutrition formula, and the whole protein type enteral nutrition formula was supported in the control group. The nutrition index, enteral nutrition tolerance and ICU hospitalization days were compared between the two groups of patients one day before and 2 weeks after nutritional support. Results: After 2 weeks of treatment, the albumin and transferrin in the experimental group were significantly increased than those of the control group(P <0.05), the enteral nutrition intolerance, high intra-abdominal pressure, diarrhea, bowel movement and the incidence of gastrointestinal bleeding were significantlylower than those of the control group(P <0.05), and the hospitalization time of ICU was obviously shortened than that of the control group(P <0.05).Conclusion: Pre-digestion enteral nutrition preparation had a good therapeutic effect on the ICU patients, it can reduce the incidence of adverse reaction of gastrointestinal tract, improve tolerance, improve the nutritional status of patients.