胃复春联合三联疗法治疗慢性萎缩性胃炎患者的临床疗效及对血清胃泌素、胃动素及降钙素原水平的影响

Clinical Efficacy of Weifuchun combined with Triple Therapy in the Treatment of Patients with Chronic Atrophic Gastritis and its Effect on the Serum Gastrin, Motilin and Procalcitonin Levels

目的:探讨胃复春联合三联疗法治疗慢性萎缩性胃炎患者的临床疗效及对血清胃泌素、胃动素及降钙素原水平的影响。方法:选择我院收治的慢性萎缩性胃炎患者96例,将其随机分为对照组与观察组,每组各48例。对照组患者给予三联抗HP治疗,观察组在对照组基础上给予胃复春片治疗,两组患者均连续治疗4周。比较两组患者的临床疗效,治疗前后血清胃泌素、胃动素、降钙素原(PCT)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平的变化。结果:治疗后,对照组患者临床总有效率(81.25%)明显低于观察组(93.75%)(P<0.05);两组患者血清胃泌素、胃动素、PCT、IL-6及TNF-α水平与本组治疗前比较均明显降低,且观察组患者治疗后以上指标均明显低于对照组(P<0.05)。结论:胃复春联合三联疗法治疗慢性萎缩性胃炎可显著提高临床疗效,可能与其有效抑制患者胃泌素及胃动素分泌,缓解炎症反应有关。

Objective: To investigate the clinical effect of Weifuchun combined with Triple therapy in the treatment of patients with chronic atrophic gastritis and the effect on the serum gastrin, motilin and procalcitonin levels. Methods: 96 cases of patients with chronic atrophic gastritis who admitted in our hospital were randomly divided into the control group and the observation group with 48 cases in each group. Patients in the control group were given Triple therapy of anti-HP infection treatment, and patients in the observation group were given Weifuchun additionally on the basis of control group. The patients in both groups were treated continuously for four weeks. The clinical efficacy were compared between the two groups after treatment. The levels of serum gastrin, motilin, calcitonin(PCT), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were compared between two groups before and after treatment. Results:After treatment, the total effective rate of control group(81.25 %) was lower than that of the observation group(93.75 %)(P<0.05), the levels of serum gastrin, motilin, PCT, IL-6 and TNF-α of both groups were significantly lower than those before treatment. Which were significantly lower in the observation group than those in the control group(P <0.05). Conclusion: Weifuchun combined with Triple therapy can significantly improve the clinical effect in the treatment of patients with chronic atrophic gastritis. It may be related to the effective inhibition of gastrin and motilin secretion and inflammatory reaction.