富血小板纤维蛋白联合人工骨粉在口腔种植引导性骨再生中的临床应用价值

Clinical Application Value of Platelet-rich Fibrin and Artificial Bone Powder in Guided Bone Regeneration in Oral Implants

目的:探讨富血小板纤维蛋白(PRF)联合人工骨粉(Bio-Oss骨粉)在口腔种植引导性骨再生中的临床应用价值。方法:选取2017年6月到2018年6月期间在我院接受口腔种植引导性骨再生手术治疗的患者80例,根据随机数字表法分为对照组(40例)和研究组(40例),对照组采用Bio-Oss骨粉联合Bio-Gide生物膜进行干预,研究组采用Bio-Oss骨粉联合PRF进行干预。比较两组患者的组织愈合情况、出血指数、探诊深度、附着丧失、植体周围的骨密度、植骨高度、成骨厚度和术后并发症。结果:研究组的组织愈合优良率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。研究组患者的出血指数、探诊深度、附着丧失均低于对照组,种植体周围的骨密度、成骨厚度均明显大于对照组,植骨高度高于对照组,差异有统计学意义(P<0.05)。两组患者的并发症发生率比较差异无统计学意义(P>0.05)。结论:PRF联合Bio-Oss骨粉可有效增加种植区骨量和种植体周围的骨密度,促进骨缺损再生和组织愈合,且无明显的并发症,在口腔种植引导性骨再生中有较好的临床应用价值。

Objective: To investigate the clinical application value of platelet-rich fibrin(PRF) and artificial bone powder in guided bone regeneration in oral implants. Methods: 80 patients who underwent oral implant-induced bone regeneration in our hospital from June 2017 to June 2018 were enrolled. According to the random number table method, they were divided into control group(40 cases) and study group(40 cases). The control group was treated with Bio-Oss bone powder combined with Bio-Gide biofilm. The study group was treated with Bio-Oss bone powder combined with PRF. The tissue healing, bleeding index, probing depth PD, attachment loss,bone density around implant, bone graft height, osteogenic thickness, and postoperative complications were compared between the two groups. Results: The excellent rate of tissue healing in the study group was 95.00%, which was higher than that in the control group80.00%. The difference was statistically significant(P<0.05). The bleeding index, probing depth PD, attachment loss in the study group were significantly lower than those in the control group, the bone density around implant and osteogenic thickness in the study group were significantly higher than those in the control group, the bone graft height was higher than that in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05). Conclusion: PRF combined with Bio-Oss bone powder can effectively increase bone mass in implanted area and bone density around implants, promote bone defect regeneration and tissue healing, and has no obvious complications. It has good clinical application value in oral implanted guided bone regeneration.