黛力新联合中药熏香治疗慢性肾衰竭伴发抑郁焦虑的效果研究

Effect of Deanxit Combined with Chinese Herbal Incense on the Chronic Renal Failure with Depression and Anxiety

目的:探讨黛力新联合中药熏香治疗慢性肾衰竭伴发抑郁焦虑的临床效果。方法:将我院自2017年10月至2018年9月收治的慢性肾衰竭伴发抑郁焦虑患者65例作为研究对象,按照随机数字表法将其分为研究组33例和对照组32例,研究组患者给予黛力新联合中药熏香进行治疗,对照组患者给予黛力新进行治疗,观察和比较两组患者抑郁自评量表(Self-rating depression scale,SDS)、焦虑自评量表(Self-Rating Anxiety Scale,SAS)及社会支持评定量表(social support rate scale,SSRS)量表评分的变化情况。结果:治疗前,两组患者SAS、SDS、SSRS评分比较差异均无统计学意义(P>0.05)。治疗后,两组患者的SAS和SDS情绪评分均较治疗前明显降低,SSRS评分均较治疗前明显升高,且研究组SAS和SDS情绪评分明显低于对照组,而SSRS评分显著高于对照组(P<0.05)。研究组患者治疗依从率为96.97%,口干、恶心、头晕、纳差等轻度不良反应发生率为30.30%,均明显高于对照组(84.38%和12.50%,P<0.05),两组患者在治疗过程中均未出现明显的恶性不良反应,研究组患者上述不良反应在停止熏香治疗后自行缓解。结论:黛力新联合中药熏香梅花香和安神香用于治疗慢性肾衰竭伴发抑郁焦虑患者能够有效的缓解患者抑郁、焦虑的不良情绪,提高社会支持和治疗依从率。

Objective: To investigate the clinical effect of Deanxit combined with traditional Chinese medicine incense on the chronic renal failure with depression and anxiety. Methods: 65 patients with chronic renal failure accompanied by depression and anxiety were admitted to our hospital from October 2017 to September 2018. According to the random number table method, they were divided into the study group(33 cases) and the control group(32 cases). The study group was treated with Deanxit combined with Chinese herbal incense, while the control group was treated with Deanxit. The changes of self-rating depression scale(SDS), self-rating Anxiety Scale(SAS) and social support rate scale(SSRS) were observed and compared between the two groups before and after treatment. Results:There was no significant difference in the SAS, SDS and SSRS scores between the two groups before treatment(P > 0.05). After treatment, the scores of SAS and SDS in both groups were significantly lower than those before treatment, and the SSRS scores were significantly higher than those before treatment. The scores of SAS and SDS in the study group were significantly lower than those in the control group, while the SSRS scores were significantly higher than those in the control group(P < 0.05). The compliance rate of study group was 96.97%, and the incidence rate of slight adverse reactions such as dry mouth, nausea, dizziness and poor acceptance was30.30%, which were significantly higher than those of the control group(84.38% and 12.50%, P < 0.05). There was no obvious malignant adverse reaction in the two groups during the treatment. The adverse reactions in study group were relieved after stopping the incense treatment. Conclusion: Deanxit combined with Chinese herbal incense plum blossom fragrance and benzoin can effectively alleviate the depression and anxiety of chronic renal failure patients with depression and anxiety, and improve the social support and treatment compliance.