脐动脉血流对预测子痫前期新生儿和产妇结局的价值分析

Analysis of the Value of Umbilical Artery Blood flow for Predicting the Outcome of Preeclampsia Neonates and Parturients

目的:探讨应用脐动脉血流用于预测子痫前期新生儿和产妇结局的临床价值。方法:选择在我院产科建档分娩的120例孕产妇作为研究对象,根据子痫前期发病情况分为子痫前期组60例与对照组60例,记录和比较两组孕产妇的一般资料、血脂、血糖水平、分娩前脐动脉血流与新生儿体重、胎盘的重量及Apgar评分,并进行相关性与危险因素分析。结果:两组孕产妇的年龄、孕次、产次、流产次数、孕周等对比差异均无统计学意义(P>0.05)。子痫前期组的血清HDL-C水平低于对照组(P<0.05),血清TC、TG、LDL-C、FBG水平高于对照组(P<0.05)。与对照组比较,子痫前期组脐动脉S/D、RI与PI值显著升高(P<0.05)。所有孕产妇都顺利完成分娩,孕产妇与新生儿都存活,子痫前期组的新生儿出生体重及Apgar评分和胎盘的重量均显著低于对照组(P<0.05)。在子痫前期组中,脐动脉S/D、RI、PI值与新生儿出生体重呈现显著负相关性(P<0.05)。多重线性回归分析显示子痫前期孕产妇的脐动脉S/D、RI、PI值为影响新生儿出生体重的独立危险因素(P<0.05)。结论:脐动脉血流与子痫前期新生儿出生体重显著相关,脐动脉S/D、RI、PI值为影响新生儿出生体重的独立危险因素,子痫前期脐动脉血流监测可为预测新生儿和产妇结局以及预后提供参考。

Objective: To investigate the clinical value of umbilical arterial blood flow for predicting the preeclampsia neonatal and maternal outcomes. Methods: 120 cases of pregnant women who gave birth in the obstetrics department of our hospital were selected and divided into 60 cases of the preeclampsia group and 60 cases of the control group according to the pre-eclampsia incidence. The general data, blood lipids and blood glucose level, umbilical arterial blood flow and neonatal birth weight and placental weight and Apgar score during the cesarean section were recorded and compared between two groups, and the correlative and risk factors analysis were performed. Results: There was no significant difference in the maternal age, pregnancy, birth, abortion, and gestational age between the two groups(P>0.05). The level of serum HDL-C in the preeclampsia group was lower than that in the control group(P<0.05), and the levels of serum TC, TG, LDL-C and FBG were higher than those in the non-eclamptic group(P<0.05). Compared with the control group, the umbilical artery S/D, RI and PI values were significantly increased in the preeclampsia group(P<0.05). All pregnant women successfully completed the delivery, both the maternal and the newborn survived. The birth weight and placental weight and Apgar score of the newborn in the preeclampsia group were significantly lower than those of the non-eclamptic group(P<0.05). In the preeclampsia group, the Pearson correlation coefficient showed significant negative correlation between the umbilical artery S/D, RI, and PI values and neonatal birth weight(P<0.05). Multiple linear regression analysis showed that the umbilical artery S/D, RI and PI values of preeclampsia were the independent risk factors for neonatal birth weight(P<0.05). Conclusion: Umbilical artery blood flow was closely related to the birth weight of preeclampsia. Umbilical artery S/D, RI and PI values are independent risk factors for neonatal birth weight. Preeclampsia umbilical artery blood flow monitoring can be used to provide references for predicting the prognosis of neonatal and maternal outcomes.