高危型人乳头瘤病毒感染与女性生殖道常见病原菌和宫颈病变的关系

The Relationship between High Risk HPV Infection and Common Pathogenic Bacteria of Female Genital Tract and Cervical Lesions

目的:探讨高危型人乳头瘤病毒(HPV)感染与女性生殖道常见病原菌以及宫颈病变的关系。方法:选取2017年1月至2018年6月于成都市妇女儿童中心医院进行宫颈癌筛查的732例妇女为研究对象,所有受试者均行HPV检测、生殖道病原菌检测,判定宫颈病变程度,统计高危型HPV感染及亚型分布特征,分析高危型HPV感染与女性生殖道常见病原菌和宫颈病变的关系。结果:732例妇女HPV感染率为44.95%,高危型HPV占85.11%,HPV-16在高危型HPV中占比最高。生殖道常见病原菌中感染率最高的是沙眼衣原体,感染率为18.99%,存在女性生殖道常见病原菌感染者高危型HPV的检出率高于未感染者(P<0.05),而低危型HPV检出率在女性生殖道常见病原菌感染者和未感染者无统计学差异(P>0.05)。高危型HPV检出率随着宫颈病变程度加重而升高(P<0.05)。结论:高危型HPV感染与女性常见生殖道病原菌感染和宫颈病变程度有关,高危型HPV感染率越高,发生宫颈癌的危险性越大。

Objective: To explore the relationship between high risk HPV infection and common pathogenic bacteria of female genital tract and cervical lesions. Methods: 732 cases of cervical cancer screening from January 2017 to June 2018 in Chengdu women’s and children’s Center Hospital were selected as the research subjects. All subjects underwent HPV test and genital tract pathogen detection, determine the degree of cervical lesions. The distribution characteristics of statistical high risk HPV infection and subtype were counted, the relationship between high risk HPV infection and common pathogens and cervical lesions in female genital tract were analyzed. Results: The rate of HPV infection in 732 women was 44.95%, high risk HPV accounted for 85.11%, HPV-16 was the highest in high risk HPV. The most common infection among genital tract pathogens was Chlamydia trachomatis, the infection rate was 18.99%,the prevalence of high risk HPV in female genital tract infections was higher than that in those without infection, and the difference was statistically significant(P<0.05). There was no significant difference in the detection rate of low risk HPV among female genital tract pathogens and those without infection(P>0.05). The high risk HPV detection rate gradually increased with the severity of cervical lesions(P<0.05). Conclusion: High risk HPV infection is associated with the common genital tract infection and the degree of cervical lesions in women, and the higher the infection rate of high risk HPV, the greater the risk of cervical cancer.