HIV感染患者血清IL-2、IL-16水平和CD4细胞计数的相关性分析

Correlative Analysis of the Serum il-2, il-16 Levels with CD4 Cell Counts in the HIV-infected Patients

目的:探讨人类免疫缺陷病毒(HIV)感染患者血清白细胞介素-2(IL-2)、白细胞介素-16(IL-16)水平和CD4细胞计数的相关性。方法:选择2017年3月至2018年3月我院接诊的50例HIV感染患者作为观察组及同期于我院进行体检的健康人群40例作为对照组。检测和比较两组血清IL-2、IL-16与CD4细胞计数,并分析观察组血清IL-2、IL-16与CD4细胞计数的相关性。结果:观察组患者血清IL-2、IL-16水平及CD4细胞计数显著低于对照组,差异具有统计学意义(P<0.05);Pearson相关分析结果显示观察组患者血清IL-2、IL-16水平与CD4细胞计数呈显著正相关(r=0.514,r=0.499,P<0.05)。结论:HIV感染患者血清IL-2、IL-16水平显著下调,并与CD4细胞计数呈显著正相关,可在一定程度上反映HIV感染的严重度。

Objective: To study Analysis of the Correlation between serum il-2, il-16 levels and CD4 cell counts in hiv-infected patients. Methods: 50 patients with HIV infection admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 40 healthy people who underwent physical examination in our hospital during the same period as the control group, the serum il-2, il-16 and CD4 cell counts in the two groups were detected and compared, and the correlation between serum il-2, il-16 and CD4 cell counts in the observation group was analyzed. Results: Serum il-2, il-16 levels and CD4 cell counts in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). Pearson correlation analysis showed that serum il-2 and il-16 levels in the observation group were significantly positively correlated with CD4 cell count(r=0.514,r=0.499, P<0.05). Conclusion: Serum il-2 and il-16 levels of hiv-infected patients were significantly down-regulated and positively correlated with CD4 cell count, which can reflect the severity of HIV infection to some extent.