产甘油假丝酵母HOG途径应答研究进展

Advances in the HOG pathway of Candida glycerinogenes

产甘油假丝酵母(Candida glycerinogenes)是工业甘油生产菌株,具有多重高抗逆、生长迅速、糖代谢高效等优点,是优良的工业宿主菌株.高渗甘油(high osmolarity glycerol, HOG)应答途径是真核细胞应答高渗透压胁迫的关键响应机制.本文从产甘油酵母HOG途径的生物信息学分析、MAP激酶Hog1对细胞表型、甘油转运和合成、氨基酸的合成与转运调控进行阐述,为进一步理解该酵母的HOG应答途径和抗逆机制奠定了基础.

Candida glycerinogenes has been applied in the bioproduction of glycerol at industrial scale. It is an excellent industrial host with high tolerance to multistress, rapid cell growth, and glucose consumption. High osmolarity glycerol pathway(HOG) is a key regulatory mechanism in the stress response of eukaryotic cell. In this review, we summarize the components of HOG pathway and the effects of protein HOG1 on cell phenotype and the transportation and synthesis of glycerol and amino acids in C. glycerinogenes to further understand its HOG pathway and stress tolerance mechanism.