丹蒌片治疗经皮冠状动脉介入治疗后急性心肌梗死冠状动脉微循环障碍的临床疗效

Clinical effect of Danlou tablets on coronary microcirculation disturbance in patients with acute myocardial infarction after percutaneous coronary intervention

目的丹蒌片治疗经皮冠状动脉介入治疗(PCI)后急性心肌梗死冠状动脉微循环障碍的临床疗效。方法选取宁德市闽东医院2017年9月-2018年2月收治的急性心肌梗死冠状动脉微循环障碍患者80例,随机分为对照组和观察组,各40例。对照组患者给予常规治疗,观察组患者在对照组基础上给予丹蒌片治疗,两组患者均持续治疗12周。比较两组患者临床疗效、心电图改善程度、心脏结构及功能,并观察两组患者不良反应发生情况。结果观察组患者临床疗效优于对照组,心电图改善程度优于对照组(P<0.05)。治疗前后两组患者右心房内径、左心房内径、右心室内径、左心室内径比较,差异无统计学意义(P>0.05);治疗前两组患者射血分数比较,差异无统计学意义(P>0.05);治疗后观察组患者射血分数高于对照组(P<0.05)。两组患者治疗期间未见严重不良反应。结论丹蒌片治疗PCI后急性心肌梗死冠状动脉微循环障碍的临床疗效确切,可有效改善患者冠状动脉微循环障碍,且安全性较高。

Objective To investigate the clinical effect of Danlou tablets on coronary microcirculation disturbance in patients with acute myocardial infarction after PCI.Methods A total of 80 cases of patients with acute myocardial infarction were selected from September 2017 to February 2018 in Mingdong Hospital,which were randomly divided into control group and observation group,40 cases in each groups.The control group were given routine treatment,while the observation group were given Danlou tablets based on control group.Both groups were treated continuously for 12 weeks.The clinical efficacy,electrocardiogram improvement,cardiac structure and function were compared between the two groups,and the adverse reactions during treatment were observed.Results The clinical effect of the observation group was better than control group,and the improvement of ECG was better than control group(P<0.05).There was no significant differences in the size of the right atrium,left atrium,right ventricle or left ventricle between the two groups before and after treatment(P>0.05);there was no significant difference in ejection fraction between the two groups before treatment(P>0.05);after treatment,the ejection fraction of the observation group was higher than control group(P<0.05).There were no serious adverse reactions between the two groups during treatment.Conclusion Danlou tablets is effective for coronary microcirculation disturbance in acute myocardial infarction after PCI,it can effectively improve coronary microcirculation disturbance,and with high safety.