万古霉素联合腰大池持续外引流治疗颅内感染的临床效果

Clinical effect of vancomycin combined with continuous external drainage of lumbar cistern for intracranial infection

目的探讨万古霉素联合腰大池持续外引流治疗颅内感染的临床效果。方法选取资阳市第一人民医院2015年1月-2018年3月收治的颅脑术后发生颅内感染患者82例,随机分为对照组与观察组,各41例。对照组患者予以万古霉素抗感染治疗,观察组患者在对照组基础上予以腰大池持续外引流治疗。比较两组患者临床效果,治疗前后颅内压,脑脊液中白细胞计数、葡萄糖及蛋白质含量。结果观察组患者临床效果优于对照组(P<0.05)。治疗前两组患者颅内压,脑脊液中白细胞计数、葡萄糖及蛋白质含量比较,差异无统计学意义(P>0.05);治疗后观察组患者颅内压,脑脊液中白细胞计数、蛋白质含量低于对照组,脑脊液中葡萄糖含量高于对照组(P<0.05)。结论万古霉素联合腰大池持续外引流治疗颅内感染的临床效果明显,可有效改善患者颅内感染症状,提高治疗有效率,且安全性高。

Objective To investigate the effect of clinical effect of vancomycin combined with continuous external drainage of lumbar cistern for intracranial infection.Methods A total of 82 cases of patients with intracranial infection were selected from January 2015 to March 2018 in First People’s Hospital of Ziyang,which were randomly divided into control group and observation group,41 cases in each group.The control group was treated with vancomycin anti-infection,the observation group was treated with continuous external drainage of lumbar cistern based on control group.Clinical effect,intracranial pressure and cerebrospinal fluid white blood cell count,glucose and protein levels before and after treatment were compared between the two groups.Results The clinical curative effect of the observation group was better than the control group(P<0.05).Before treatment,there was no significant differences in intracranial pressure,leukocyte count,glucose or protein level between the two groups(P>0.05).After treatment,the observation group of the levels of intracranial pressure and leukocytes and protein in cerebrospinal fluid of were lower than control group,the level of glucose in cerebrospinal fluid was higher than control group(P<0.05).Conclusion Vancomycin combined with continuous external drainage of lumbar cistern have an exact clinical effect for intracranial infection,it can effectively improve the symptoms of intracranial infection,improve the effective rate of treatment,and with high safety.