“调任通督针刺法”治疗肾虚型早发性卵巢功能不全疗效观察

Observation on therapeutic effect of “Tiaoren Tongdu acupuncture” on premature ovarian insufficiency of kidney deficiency

目的:比较"调任通督针刺法"与口服雌二醇片/雌二醇地屈孕酮片(芬吗通)治疗肾虚型早发性卵巢功能不全患者的临床疗效。方法:将50例肾虚型早发性卵巢功能不全患者随机分为观察组、对照组,每组25例。观察组采用"调任通督针刺法",针刺百会、中脘、关元、气海、中极、腰阳关、腰俞、命门等穴,隔日1次,1个月为一疗程;对照组口服芬吗通治疗,每次1片,每日1次,1个月为一疗程。两组均连续治疗3个疗程,观察两组治疗前后的临床症状、月经改善情况,血清雌二醇(E_2)、促黄体生成素(LH)、促卵泡生成素(FSH)的变化。结果:两组治疗后临床症状及月经情况均有改善(P<0.01),血清FSH、LH水平均显著降低(P<0.01),而血清E_2水平均显著升高(P<0.01)。观察组月经改善率、月经改善时间与对照组比较差异无统计学意义(P>0.05),但在停经复发率、临床症状评分改善方面优于对照组(P<0.05);观察组治疗后血清E_2水平低于对照组(P<0.05),血清LH、FSH水平明显低于对照组(P<0.01)。观察组不良反应率为4.0%(1/25),低于对照组的36.0%(9/25,P<0.05)。结论:"调任通督针刺法"对于肾虚型早发性卵巢功能不全具有很好的疗效,在改善患者的临床症状、停经复发及降低血清FSH、LH水平上优于芬吗通治疗,且不良反应少。

Objective To observe the clinical efficacy of "Tiaoren Tongdu acupuncture" and oral estradiol and dydrogesterone tablets(femoston) on premature ovarian insufficiency of kidney deficiency. Methods A total of 50 patients with premature ovarian insufficiency of kidney deficiency were randomized into an observation group and a control group, 25 cases in each one.In the observation group,"Tiaoren Tongdu acupuncture" was applied at Baihui(GV 20),Zhongwan(CV 12), Guanyuan(CV 4), Qihai(CV 6), Zhongji(CV 3), Yaoyangguan(GV 3), Yaoshu(GV 2), Mingmen(GV 4),etc. once every 2 days, 1 month as a course. In the control group, femoston was prescribed for oral administration, one tablet per time, once a day, 1 month as a course. Both of the two groups were given consecutive treatment for 3 courses. Before and after treatment, the clinical symptoms, menstrual improvement as well as the changes of estradiol(E2), luteotrophic hormone(LH) and follicle-stimulating hormone(FSH) in serum were observed in the two groups. Results After treatment, the clinical symptoms and menstrual conditions were improved(P<0.01), the levels of FSH and LH were significantly reduced(P<0.01), and the levels of E2 were significantly increased in the two groups(P<0.01). There were no significant difference in menstrual improvement rate and menstrual improvement time between the observation group and the control group(P<0.05), the recurrence rate of menopause and clinical symptom score improvement in the observation group were superior to the control group(P<0.05). In the observation group, the level of E2 in serum was lower and the levels of FSH and LH in serum were significantly lower than those in the control group(P<0.05, P<0.01). In the observation group, the rate of adverse reaction was 4.0%(1/25), which was lower than 36.0%(9/25) in the control group(P<0.05). Conclusion "Tiaoren Tongdu acupuncture" has better therapeutic effect for premature ovarian insufficiency of kidney deficiency. It is superior to femoston in improving clinical symptoms and recurrence rate of menopause as well as reducing the levels of FSH and LH.