摘要
脊柱裂是神经管畸形的表型之一,由遗传与环境等因素共同影响。与脊柱裂发生相关的基因很多,主要基因和动物模型主要集中在信号通路上。本文就脊柱裂的发病机理和关键基因的关系的研究进展进行综述,以期进一步阐明脊柱裂的发病机制。
Spinal bifida is one of the phenotypes of neural tube defects, which are influenced by genetic and environmental factors. There are many genes involved in the occurrence of spinal bifida, and the main genes and animal models are mainly concentrated in the signaling pathway. This article reviews the research progresses on pathogenesis of spinal bifida and relationship between key genes, and further clarifies the pathogenesis of spinal bifida, and achieves more effective prevention and control of neural tube defects.
作者
刘玉
王建华
赵丽娇
Liu Yu;Wang Jianhua;Zhao Lijiao(Beijing Municipal Key Laboratory of Environment&Viral Oncology,School of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China;Beijing Municipal Key Laboratory of Child Development and Nutriomics,Department of Translational Medicine,Capital Institute of Pediatrics,Beijing 100020,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2019年第6期622-628,共7页
Chinese Journal of Neuromedicine
基金
国家重点研发计划(2018YFC1002500)
国家自然科学基金(81571443、81600984、81801451)
北京市自然科学基金(7172038).
关键词
脊柱裂
基因
信号通路
表型
神经管
Spinal bifida
Gene
Signal pathway
Phenotype
Neural tube
