补肾通痹汤治疗腰椎间盘突出症的效果及对炎性因子的影响

Effect of Bushen Tongbi Decoction on lumbar disc herniation and its influence on inflammatory factors

目的研究补肾通痹汤治疗腰椎间盘突出症(LDH)的效果及对炎性因子的影响。方法选择2017年1月~2018年6月石家庄市第一医院接受治疗的LDH患者80例进行研究。按随机数字表法将患者分成观察组及对照组,每组各40例。对照组给予牵引及理疗治疗,观察组在对照组的治疗基础上再增加补肾通痹汤,两组均治疗3周。比较两组临床效果,治疗前及治疗3周后的功能及疼痛评分,炎性因子以及不良反应发生率。结果观察组的总有效率高于对照组(P < 0.05)。治疗后两组的视觉模拟评分及Oswestry功能障碍指数(ODI)评分均低于治疗前,且观察组低于对照组;而日本骨科协会评估治疗(JOA)评分高于治疗前,且观察组高于对照组(P < 0.05)。治疗后两组的C反应蛋白、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α及白细胞介素-6均低于治疗前(P < 0.05),且观察组低于对照组(P < 0.05)。观察组药物不良反应的总发生率与对照组比较,差异无统计学意义(P > 0.05)。结论应用补肾通痹汤治疗LDH的效果与安全性均较好,还可有效地改善患者的功能及疼痛评分,以及机体的炎症状态。

Objective To study the effect of Bushen Tongbi Decoction on lumbar disc herniation (LDH) and its influence on inflammatory factors. Methods From January 2017 to September 2018, 80 LDH patients treated in the First Hospital of Shijiazhuang were studied. According to random number table method, patients were randomly divided into observation group and control group, there were 40 cases in each group. The control group was treated with traction and physiotherapy, the observation group was treated with Bushen Tongbi Decoction on the basis of control group, both groups were treated for 3 weeks. The efficacy, functional and pain score, inflammatory factor, and incidence of adverse reaction before treatment and 3 weeks after treatment was compared between the two groups. Results The total effective rate of the observation group was higher than the control group (P < 0.05). After treatment, the visual analogue scale (VAS) and osuesery dability index (ODI) score in the two groups was lower than before treatment, and the observation group was lower than the control group, the Japanese Orthpaedic assoiationscores (JOA) score was higher than before treatment, and the observation group was higher than that of the control group (P < 0.05). The C-reactive protein, interleukin-1β, tumor necrosis factor-α and IL-6 were lower in the two groups after treatment than before treatment (P < 0.05), and lower in the observation group than in the control group (P < 0.05). The incidence of adverse drug reactions in the observation group was not significantly different compared with that in the control group (P > 0.05). Conclusion The efficacy and safety of Bushen Tongbi Decoction in the treatment of LDH is good. It can also effectively improve the function, pain score and inflammatory state of the patients.