羟考酮静脉注射用于无痛结肠镜检查术的半数有效剂量

50% effective dose of oxycodone for intravenous injection in preoperative analgesia for patients taking painless colonoscopy

目的 采用序贯法测定羟考酮静脉注射用于无痛结肠镜检查术患者的半数有效剂量(ED50)。方法 选择2017年12月至2018年7月于本院内镜中心行无痛结肠镜检查术患者30例,美国麻醉医师协会(ASA)分级Ⅰ~Ⅱ级,根据序贯法增减给药,麻醉诱导前5 min时第1例患者静脉注射羟考酮5.0mg,相邻剂量梯度为0.5 mg,若上一例患者镇痛效果满意,则下一例患者剂量减少0.5 mg;若上一例患者镇痛效果不满意,则下一例患者剂量增加0.5 mg。序贯给药后根据患者是否发生体动反应和呼吸抑制来评估镇痛效果。采用Dixon and Massey序贯分配试验法公式计算羟考酮静脉注射用于无痛结肠镜检查术患者的ED50和95%可信区间。结果 静脉注射羟考酮用于无痛结肠镜检查术患者的ED50为2.9 mg,95%可信区间为2.3~3.4 mg。结论 采用序贯法测得的静脉注射羟考酮用于无痛结肠镜检查术患者的ED50为2.9mg,且此法简便、高效、准确性高。

Objective To determine the half effective dose(ED50)of oxycodone for intravenous injection in patients taking painless colonoscopy using sequential method.Methods From December 2017 to July 2018,30 patients with painless Colonoscopy in endoscopy center of our hospital.Thirty patients taking painless colonoscopy and who were gradeⅠtoⅡof American Society of Anesthesiologists(ASA)were enrolled,According to the sequential method of increasing or decreasing administration,the first patient was intravenously injected 5.0 mg oxycodone 5 minutes before anesthesia induction,and the adjacent dose gradient was 0.5 mg.If the previous patient had satisfactory analgesic effect,the next patient’s dose was reduced by 0.5 mg.If the last patient's analgesic effect was not satisfactory,the next patient’dose was increased by 0.5 mg.After sequential administration,the analgesic effect was evaluated according to whether the patient had a body motion reaction or respiratory depression.The ED50 and 95%confidence intervals of preoperative analgesia for the patients were calculated using the Dixon and Massey sequential distribution test formula.Results The ED50 of oxycodone for intravenous injection was 2.9 mg,with a 95%confidence interval of 2.3 to 3.4 mg.Conclusion ED50 of oxycodone for intravenous injection in patients taking painless colonoscopy is 2.9 mg,and the method was simple,efficient,and accurate.