中药熏洗联合血府逐瘀汤改善老年晚期恶性肿瘤患者癌性疼痛的临床研究

Fumigation with Chinese medicine combining Xuefu Zhuyu Decoction for improving cancer pain in elderly patients with advanced malignant tumor

目的 探讨中药熏洗联合血府逐瘀汤改善老年晚期恶性肿瘤患者癌性疼痛的临床疗效。方法 选取2017年1—12月晚期恶性肿瘤患者100例为调查对象,随机分成两组,每组50例,对照组给予用盐酸羟考酮缓释片治疗,研究组在对照组基础上加用中药熏洗、血府逐瘀汤(内服)治疗,两组均治疗14d,比较两组患者疼痛治疗效果。结果 研究组治疗总有效率优于对照组(90.00%比64.00%),差异有统计学意义(P<0.01);治疗后,两组患者NRS评分均明显下降、KPS评分均明显升高(P<0.01),研究组患者的NRS评分显著低于对照组、KPS评分明显高于对照组(P<0.01)。研究组患者止痛起效时间及爆发疼痛次数均少于对照组(P<0.01);研究组患者盐酸羟考酮缓释片日均用量显著少于对照组(P<0.01);研究组患者便秘、恶心、呕吐、头晕等不良反应发生率均明显低于对照组(P<0.05)。结论 中药熏洗联合血府逐瘀汤能明显提高恶性肿瘤患者的疼痛治疗效果,显著降低盐酸羟考酮缓释片的日均用量以及患者不良反应的发生。

Objective To observe the effect of fumigation with Chinese medicine combining Xuefu Zhuyu Decoction for improving cancer pain in elderly patients with advanced malignant tumor.Methods A total of 100 patients with advanced malignant tumor treated at our hospital from January to December,2017 were randomly divided into a control group and a study group,50 for each group.The control group were treated with oxycodone hydrochloride.The study group were treated by fumigation with Chinese medicine and Xuefu Zhuyu Decoction.The two groups were treated for 14 d.The treatment effects were compared between the two groups after the treatment.Results The total effective rate of the study group was higher than that of the control group(90.00%vs.64.00%).After the treatment,the score of NRS decreased and the score of KPS increased in both groups(P<0.01);the score of NRS was lower and the score of KPS was higher in the study group than in the control group(P<0.01).The onset time,and the frequency of outbreaks of pain were lower in the study group than in the control group(P<0.01).The average daily dosage of oxycodone hydrochloridein was lower in the study group than in the control group(P<0.01).The incidence of adverse reactions such as constipation,nausea,vomiting,and dizziness was significantly lower in the study group than in the control group(P<0.05).Conclusion Fumigation Chinese medicine combining Xuefu Zhuyu Decoction for patients with advanced malignant tumor can significantly improve their pain,and significantly reduce the average daily dosage of oxycodone hydrochloridein and adverse reactions.