从化地区儿童呼吸道疾病病毒检测的临床意义

Clinical significance of detection of respiratory disease viruses in children in Conghua

目的 探究从化地区儿童呼吸道疾病病毒检测的临床意义。方法 选取2015年1月至2018年1月本院诊治的50例呼吸道感染疾病患儿为实验组,同时纳入健康儿童50例为对照组,两组患儿均行血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)检测,观察两组受检者血清PCT、hs-CRP水平与实验组治疗后血清PCT、hs-CRP改善情况,鼻咽分泌物检测各种呼吸道病毒,总结病毒病原体阳性检出率。结果 实验组血清PCT、hs-CRP水平均高于对照组[(11.68±3.59)ng/ml比(0.32±0.18)ng/ml,(43.67±10.68)mg/L比(2.13±1.02)mg/L],组间比较,t=6.27、7.70,均P<0.05;实验组治疗3、6、10d后PCT(r=﹣0.753,P<0.05),hs-CRP(r=﹣0.757,P<0.05)均与疾病改善率呈负相关;实验组鼻病毒、冠状病毒、肠道病毒、腺病毒、流感病毒阳性检出率分别为12.00%、10.00%、20.00%、36.00%、22.00%。结论 检测病原体、血清降钙素原、超敏C反应蛋白对儿童呼吸道疾病病毒诊断和治疗有指导作用,可为临床诊治患者提供有效依据,值得临床大力推广应用。

Objective To explore the clinical significance of detection of respiratory disease viruses in children in Conghua.Methods 50 children infected by respiratory disease viruses and diagnosed and treated at our hospital from January,2015 to January,2018 were selected as an experimental group,and 50 healthy children during the same period a control group.The serum levels of calcitonin original(PCT)and hypersensitive c-reactive protein(hs-CRP)were detected.The levels of PCT and hs-CRP in the control group and in the experimental group before and after the treatment were observed.The various respiratory viruses in nasopharyngeal secretion were detected,and the viral pathogen positive detection rate was summarized.Results The serum levels of PCT and hs-CRP were higher in the experimental group than in the control group[(11.68±3.59)ng/ml vs.(0.32±0.18)ng/ml and(43.67±10.68)mg/L vs.(2.13±1.02)mg/L;t=6.27 and 7.70,both P<0.05].After treatment for 3,6,and 10 days,the PCT(r=-0.753,P<0.05)and hs-crp(r=-0.757,P<0.05)negatively correlated with the disease improvement rate in the experimental group.The positive detection rates of rhinovirus,coronavirus,enterovirus,adenovirus,and influenza virus in the experimental group were 12.00%,10.00%,20.00%,36.00%,and 22.00%,respectively.Conclusion The detection of pathogens and serum levels of PCT and hs-CRP can guide the diagnosis and treatment of children infected by respiratory disease viruses,and provide effective basis for the clinical diagnosis and treatment,so it is worth for clinical promotion and application.