玻璃酸酶辅助曲安奈德治疗瘢痕疙瘩的有效性和安全性

Hyaluronidase and triamcinolone acetonide in treatment of keloid

目的 探讨和分析玻璃酸酶辅助曲安奈德治疗瘢痕疙瘩的临床价值。方法 随机选择2016年1月至2018年12月本院收治的瘢痕疙瘩患者100例,通过随机数字表法分为观察组51例和对照组49例,观察组采用玻璃酸酶和曲安奈德治疗,对照组采用曲安奈德治疗,比较分析两组临床治疗情况、临床指标变化情况及不良反应发生情况。结果 与对照组相比,观察组治愈率[58.82%(30/51)]和总有效率[98.04%(50/51)]均明显提高,而无效率[1.96%(1/51)]则明显降低,差异均具有统计学意义(均P<0.05);观察组治疗后瘢痕组织隆起高度(2.13±0.32)mm,疼痛评分(2.08±0.31)分,瘙痒评分(1.29±0.23)分,均明显低于对照组,差异均具有统计学意义(均P<0.05);观察组月经提前、色素沉着、毛细血管扩张等不良反应总发生率7.84%(4/51),明显低于对照组,差异具有统计学意义(均P<0.05)。结论 玻璃酸酶辅助曲安奈德对于瘢痕疙瘩患者临床治疗有效性的提升及安全性的保障均呈现十分重要的临床价值。

Objective To explore and analyze the clinical value of hyaluronidase and triamcinolone acetonide in the treatment of keloid.Methods 100 patients with keloid admitted to our hospital from January,2016 to December,2018 were selected and divided into an observation group(51 cases)and a control group(49 cases)by random number table.The observation group were treated with hyaluronidase and triamcinolone acetonide,while the control group with triamcinolone acetonide.The clinical treatment effects,clinical indicators,and adverse reactions of the two groups were analyzed and compared.Results The cured rate,total effective rate,and the inefficiency rate of the observation group were 58.82%(30/51),98.04%(50/51),and 1.96%(1/51),which were better than those in the control group,with statistical differences(all P<0.05).The height of scar tissue eminence,the pain score,and the pruritus score were(2.13±0.32)mm,(2.08±0.31)and(1.29±0.23)in the observation group,which were lower than those in the control group(all P<0.05).The total incidence of adverse reactions,such as premenstrual menstruation,pigmentation,and telangiectasia,was 7.84%(4/51)in the observation group,which was lower than that in the control group(P<0.05).Conclusion Hyaluronidase and triamcinolone acetonide keloid patients is effective and safe.