广州市流浪精神分裂症患者暴力风险与血脂水平的相关性研究

Correlation study between violent risk and blood lipid levels in vagrant schizophrenia patients in Guangzhou

目的研究广州市流浪精神分裂症患者暴力风险与血脂水平的相关性。方法选取2018年4~9月白云精神病康复医院、广州市民政局精神病院收治的180例符合《美国精神疾病诊断与统计手册第五版》(DSM-V)诊断标准的急性期未用药的流浪精神分裂症患者作为研究组,另选取同期招募的180名健康志愿者作为对照组。比较两组的血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和极低密度脂蛋白(VLDL)水平;采用阳性阴性症状量表(PANSS)、暴力风险评定量表(DASA)分析暴力风险与血脂水平的关系。结果研究组的TC、HDL、LDL水平均低于对照组,差异有统计学意义(P<0.05);两组的TG、VLDL水平比较,差异无统计学意义(P>0.05)。TC、LDL水平与DASA评分均成负相关(r=-0.299、-0.262,P<0.05)。结论新入院的精神分裂症急性期患者需要及时检测TC、HDL、LDL,但对降低以上三个指标的治疗方案应该谨慎使用,为暴力风险评估提供了三个生物学参考指标。

Objective To study the correlation between violent risk and blood lipid levels in vagrant schizophrenia patients in Guangzhou. Methods A total of 180 patients with acute vaginal schizophrenia patients, who were not treated with drugs and conformed to the diagnostic criteria of American Diagnostic and Statistical Manual of Mental Disorders- Fifth Edition (DSM-V), admitted to the Baiyun Jingkang Hospital and Guangzhou Civil Affairs Bureau Mental Hospital from April to September 2018 were selected as the study group, and another 180 healthy volunteers during the same period were selected as the control group. The levels of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were compared between the two groups. The positive and negative symptom scale (PANSS) and the dynamic appraisal of situational aggression (DASA) were used to analyze the relationship between violent risks and blood lipid levels. Results The levels of TC, HDL and LDL in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in levels of TG and VLDL between the two groups (P>0.05). The levels of TC and LDL were negatively correlated with DASA scores (r=-0.299,-0.262, P<0.05). Conclusion Patients with schizophrenia in the acute phase need to be tested for TC, HDL, and LDL in a timely manner, but treatment options that reduce the above three indicators should be used with caution, which provide three biological reference indicators for violent risk assessment.