非小细胞肺癌液体活检技术研究进展

Research progress in the liquid biopsy in patients with non-small cell lung cancer

随着精准医学和个体化治疗在肿瘤领域的发展,采用肿瘤分子生物学特性进行监测的要求越来越高,液体活检技术以其独有的无创性、便捷性、高重复性等特点在临床上得到了广泛关注,在未来有着巨大的发展潜力。非小细胞肺癌(NSCLC)占肺癌病人85%~90%,针对NSCLC,该文以液体活检循环肿瘤细胞、循环肿瘤DNA和外泌体,对NSCLC病人的临床应用做如下综述。

With the development of precision medicine and individualized treatment in the field of cancer therapy,the demand of monitoring tumor molecular biology characteristics is elevated.Liquid biopsy technology has attracted extensive attention in clinical practice due to its unique features of noninvasive,convenient and high repeatability and has the huge development potential in the future.Nonsmall cell lung cancer(NSCLC)accounts from 85%to 90%in patients with lung cancer.The clinical application of liquid biopsy of circulating tumor cells,circulating tumor DNA and exosomes in patients with NSCLC were reviewed as follows.