眼底激光联合羟苯磺酸钙治疗糖尿病视网膜病变60例疗效分析

Clinical analysis of fundus laser treatment combined with oralcalcium dobesilate capsules for diabetic retinopathy

目的探讨眼底激光联合羟苯磺酸钙治疗糖尿病视网膜病变的效果。方法选取2015年1月至2016年12月巴中市中心医院收治的糖尿病视网膜病变病人110例(188眼),采用随机数字表法分为两组,对照组50例(84眼)予以单纯眼底激光治疗,观察组60例(104眼)实施眼底激光联合羟苯磺酸钙治疗。比较两组的临床疗效。结果两组最佳矫正视力(BCVA)均有效改善,观察组激光治疗6个月后BCVA值超过对照组(P<0.05)。两组治疗后视网膜新生血管荧光素渗漏面积均减小(P<0.05),观察组激光治疗后3个月、6个月视网膜新生血管荧光素渗漏面积(3.42±0.65)、(2.75±0.54)mm^2均明显小于对照组(4.19±0.77)、(3.32±0.65)mm^2(P<0.05)。两组治疗后视网膜厚度(CMT)均降低(P<0.05),观察组激光治疗后3个月、6个月CMT值均明显小于对照组(P<0.05)。两组激光治疗后并发症发生率相对接近(P>0.05)。结论针对糖尿病视网膜病变病人实施眼底激光联合羟苯磺酸钙治疗,可以取得明显的效果,对于提高病人视力,改善病人预后具有积极意义。

Objective To explore and analyze the method and effect of fundus laser combined with calcium dobesilate in the treatment of diabetic retinopathy.Methods From January 2015 to December 2016,110 cases of patients with diabetic retinopathy in our hospital were selected and randomly divided into control group,with 50 cases(84 eyes).were treated with laser photocoagulation for treatment,and the study group,with 60 cases(104 eyes)underwent fundus laser combined with calcium dobesilate treatment.The clinical efficacy of the two groups were compared.Results After the corresponding treatment,the two groups of BCVA vision were improved effectively.6 months after surgery,BCVA detection value of the study group was significantly higher than the control group(P<0.05).The fluorescein leakage area of retinal neovascularization was significantly decreased in the two groups(P<0.05).The fluorescein leakage area of retinal neovascularization in the study group at 3 months and 6 months after surgery was significantly smaller than that in the control group[(3.42±0.65)vs.(4.19±0.77)mm^2,(2.75±0.54)vs.(3.32±0.65)mm^2,P<0.05)].The CMT values of the two groups after treatment were significantly lower(P<0.05),and the CMT values of the study group at 3 and 6 months after surgery were significantly smaller than those in the control group(P<0.05).The incidence of postoperative complications in the two groups was relatively close(P>0.05).Conclusion the treatment of diabetic retinopathy with fundus laser combined with calcium dobesilate can achieve obvious results.It has positive significance for improving the vision of patients and promoting the prognosis of patients.