胺碘酮联合美托洛尔治疗老年慢性心力衰竭的临床分析

Curative Effect of Amiodarone Combined with Metoprolol on Chronic Heart Failure in the Elderly

目的探讨胺碘酮联合美托洛尔治疗老年慢性心力衰竭的疗效,为有效治疗老年慢性心力衰竭提供方法。方法选取北京怀柔医院就诊的160例老年慢性心力衰竭患者,随机分为观察组和对照组,每组80例。观察组给予胺碘酮联合美托洛尔治疗,对照组只给予胺碘酮治疗。评估并比较2组患者治疗前后左心室射血分数(left ventricular ejection fraction,LVEF)、左心室收缩末期容积(left ventricular end systolic volume,LVESV)、左心室舒张末期容积(left ventricular end diastolic volume,LVEDV)、静息心室率水平变化;评估2组临床疗效和安全性等。结果治疗前2组LVEF、LVEDV、LVESV和静息心室率水平差异均无统计学意义(P>0.05)。与治疗前比较,治疗后2组LVEF水平均下降(P<0.05),LVEDV、LVESV、静息心室率均升高,且观察组LVEF水平显著高于对照组(P<0.05);LVEDV、LVESV、静息心室率水平显著低于对照组(P<0.05)。观察组心功能疗效有效率显著高于对照组(98.75%vs73.75%)(P<0.05)。观察组心律失常疗效有效率显著高于对照组(97.50%vs72.50%)(P<0.05)。观察组不良反应发生率(12.50%)与对照组(11.25%)比较,差异无统计学意义(P>0.05)。结论胺碘酮联合美托洛尔治疗老年慢性心力衰竭,临床疗效显著,且安全性较高,值得在临床上应用。

Objective To observe the curative effect of amiodarone combined with metoprolol on chronic heart failure in the elderly.Methods 160 elderly with chronic heart failure were selected and randomly divided into 2 groups: observation group and control group,80 in each;amiodarone was administrated to all the elderly in the 2 groups while the combination with metoprolol was added to the elderly in observation group;the left ventricular ejection fraction (LVEF),left ventricular end systolic volume (LEVSV),left ventricular end diastolic volume (LVEDV) and the level of resting ventricular rate of the elderly in both groups before and after treatment were evaluated as well as the clinical curative effect and safety,and a comparative study was made between the 2 groups.Results There existed no statistical differences in LVEF,LVEDV LVESV and the resting ventricular rate between the 2 groups before treatment (P>0.05);after treatment,the level of LVEF (P<0.05) dropped down while the levels of LVEDV,LVESVand the resting ventricular rate increased (P<0.05) in both groups;after treatment,the level of LVEF was much higher and the levels of LVEDV,LVESV and the resting ventricular rate were much lower in observation group than those in control group (P<0.05);the curative effective rate of cardiac function and that of arrhythmia in observation group were both higher than those in control group [(98.75% vs 73.75%);(98.75% vs 73.75%);P<0.05)];no statistical difference was found in the occurrence of adverse reactions between observation group (12.50%) and control group (11.25%).Conclusions Amiodarone combined with metoprolol is of obvious curative effect with a higher safety on chronic heart failure in the elderly and is worthy of wider clinical application.