肠道菌群与脑-肠-肾轴在慢性肾病中的研究进展

Research progress of intestinal flora and brain-intestinal-kidney axis in chronic kidney disease

随着慢性肾病(chronic kidney disease,CKD)发病率不断增加,肾病已成为全球性重大公共卫生问题之一。据2017世界肾脏大会发布的最新全球肾病健康报告显示,全球每10人当中就有1人患有肾脏疾病。近年来,越来越多的证据表明,慢性肾病患者中存在肠道菌群失调及肠道屏障功能受损的情况,且慢性肾病患者比非慢性肾病患者有更高的患痴呆和认知障碍的风险。本文就肠道菌群和脑-肠-肾轴在慢性肾脏疾病中的作用做一综述,希望通过调节肠道菌群作为靶点,来延缓慢性肾脏病及其并发症的进展。

With the increasing incidence of chronic kidney disease(CKD),it has become a major global public health problem.According to the latest Global Nephrology Health Report released by the 2017 World Kidney Congress,one out of every 10 people worldwide has kidney disease.In recent years,there has been increasing evidence of intestinal flora imbalance and impaired intestinal barrier function in CKD patients,and CKD patients have a higher risk of dementia and cognitive impairment than non-CKD patients.This article reviews the role of intestinal flora and brain-intestinal-kidney axis in chronic kidney disease,and hopes to delay the progression of chronic kidney disease and its complications by regulating the intestinal flora as a target.