摘要
Various isoforms of laminins are present in the basement membranes complexed with other structural proteins.In the central nervous system(CNS),they are primarily localized to the basement membranes of blood vessels and reactive astrocytes.Limited amounts of various laminin isoforms are also associated with neuronal cell bodies and axons,which are referred to as“neuronal”laminins(Yamamoto et al.,1988).They exist in a soluble form,free from other basement membrane proteins.Neurons either produce these soluble laminins or acquire them from astroglial cells.Laminin stimulates neuritogenesis and confers neuroprotection in vitro,but their exact role of these neuronal soluble laminins in the CNS is yet unknown.
