摘要
梅毒是由密螺旋体苍白亚种( Treponema pallidum subsp. pallidum , Tp)感染引起的慢性系统性性传播疾病,流行于中低等收入国家。越来越多的临床病例表明清除Tp感染需要加强公共卫生筛查和治疗,而接种疫苗是预防Tp感染极有价值和首选的方法。本文概述了研制Tp疫苗的必要性,总结疫苗研究过程中候选抗原的相关信息及递送系统,分析Tp疫苗发展策略。
Syphilis is a sexually transmitted infection caused by Treponema pallidum subsp. Pallidum (T. pallidum), Over 90% of syphilis cases occur in low- and middle-income countries. Studies indicated that elimination of T. pallidum requires enhanced public health screening, treatment and vaccination. This article provides an overview of the need for development of a syphilis vaccine, summarizes the information and delivery system and candidate antigens in development, and analyzes the development strategies for T. pallidum vaccine.
作者
郑康
刘安元
吴移谋
ZHENG Kang;LIU Anyuan;WU Yimou(Institution of Pathogenic Biology,Medical College,University of South China,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang,421001,China;The Second Affiliated Hospital of University of South China,Hengyang 421001,China)
出处
《微生物与感染》
2019年第3期180-184,共5页
Journal of Microbes and Infections
基金
国家自然科学基金(81471576、81702046)
关键词
梅毒螺旋体苍白亚种
疫苗
候选抗原
递送系统
发展策略
Treponema pallidum subsp. pallidum
vaccine
candidate antigens
delivery system
development strategy
