莫哈韦丝兰化学成分的研究

Study on the constituents of Yucca schidigera Roezl(Mojave)

[目的]对莫哈韦丝兰的化学成分进行系统研究。[方法]利用正相硅胶、反相ODS、SephadexLH-20及高效液相色谱等多种色谱法进行分离纯化,并通过理化性质及波谱分析鉴定化合物结构。[结果]从莫哈韦丝兰70%乙醇提取物中分离鉴定了14个单体化合物,分别为咖啡酸(1)、β-羟基-3-甲氧基-4-羟基苯乙酮(2)、1-O-β-D-glucopyranosyl-2-hydroxy-4-allylbenzene(3)、2-O-(4-hydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid(4)、对羟基苯甲酸(5)、原儿茶酸(6)、4-羟基-3-甲氧基苯甲酸(7)、丁香酸(8)、对羟基苯甲醛(9)、原儿茶醛(10)、麦芽酚(11)、5-hydroxymaltol(12)、5-羟甲基糠醛(13)和4,4-二甲基-1,7-庚二酸(14)。[结论]化合物2~4、7~14为首次从丝兰属植物中分离得到的化合物,5、6为首次从该种植物中分离得到的化合物。

[Objective]The purpose of this thesis is to study the constituents from Y.schidigera systematically.[Methods]The silica gel,ODS,Sephadex LH-20 column chromatographies and preparative HPLC chromatography were used to conduct the isolation experiments,and the identifications of isolates were completed by the spectroscopic and chemical reaction methods.[Results]Fourteen compounds were obtained and identified as caffeic acid(1),β-hydroxypropiovanllone(2),1-O-β-D-glucopyranosyl-2-hydroxy-4-allylbenzene(3),2-O-(4-hydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid(4),p-hydroxyl benzoic acid(5),protocatechuic acid(6),4-hydroxy-3-methoxy-benzoic acid(7),syringic acid(8),p-hydroxy-benzaldehyde(9),protocatechuic aldehyde(10),maltol(11),5-hydroxymaltol(12),5-hydroxy methyl furfura(13)and 4,4-dimethyl-1,7-pimelic acid(14),respectively.[Conclusion]Compounds 2-4,7-14 were obtained from Yucca genus firstly,and compounds 5 and 6 were isolated from Y.schidigera for the first time.