阿司匹林联合氯吡格雷对短暂性脑缺血发作的临床效果观察

Observation on clinical effect of aspirin combined with clopidogrel on transient ischemic attack

目的探讨短暂性脑缺血发作采用阿司匹林联合氯吡格雷治疗的临床效果。方法60例短暂性脑缺血发作患者,采用随机数字表法分为对照组和观察组,每组30例。对照组患者采用阿司匹林治疗,观察组患者采用阿司匹林联合氯吡格雷治疗。比较两组患者治疗前后血流动力学指标以及不良反应发生情况。结果治疗前,两组患者全血低切粘度、全血高切粘度、血浆粘度、纤维蛋白原含量比较差异无统计学意义(P>0.05)。治疗后,观察组患者全血低切粘度(5.13±1.14)mPa·s、全血高切粘度(2.82±0.74)mPa·s、血浆粘度(0.85±0.13)mPa·s、纤维蛋白原含量(2.41±0.72)g/L明显优于对照组的(6.54±1.01)mPa·s、(3.74±0.83)mPa·s、(1.48±0.25)mPa·s、(3.54±0.81)g/L,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为6.67%,低于对照组的26.67%,差异具有统计学意义(P<0.05)。结论短暂性脑缺血发作患者采用阿司匹林联合氯吡格雷治疗的临床效果较显著,可有效改善患者血流动力学指标,降低不良反应发生率。

Objective To discuss the clinical effect of aspirin combined with clopidogrel on transient ischemic attack. Methods A total of 60 transient ischemic attack patients were divided by random number table method into control group and observation group, with 30 cases in each group. The control group was treated with aspirin, and the observation group was treated with aspirin combined with clopidogrel. The hemodynamic parameters before and after treatment and adverse reactions were compared between the two groups. Results Before treatment, both groups had no statistically significant difference in whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity and fibrin content (P>0.05). After treatment, the observation group had obviously better whole blood low shear viscosity as (5.13±1.14) mPa·s, whole blood high shear viscosity as (2.82±0.74) mPa·s, plasma viscosity as (0.85±0.13) mPa·s and fibrin content as (2.41±0.72) g/L than (6.54±1.01) mPa·s,(3.74±0.83) mPa·s,(1.48±0.25) mPa·s and (3.54±0.81) g/L in the control group. Their difference was statistically significant (P<0.05). The observation group had lower incidence of adverse reactions as 6.67% than 26.67% in the control group, and the difference was statistically significant (P<0.05). Conclusion Aspirin combined with clopidogrel shows significant clinical effect on transient ischemic attack, and it can effectively improve the hemodynamic parameters and lower the incidence of adverse reactions.