Flotillin-1在结肠癌中表达的初步研究

Study of Expression of Flotillin-1 in Colorectal Cancer

目的研究浮舰蛋白-1(Flotillin-1)在结肠癌组织中的表达及意义。方法选取2014年12月-2017年6月经病理科证实的结肠癌34例及非结肠癌病例14例。采用免疫组化方法检测病变组织和淋巴结的Flotillin-1蛋白的表达并进行对比。结果结肠癌中的Flotillin-1阳性率为58.8%,显著高于非结肠癌病例组的14.3%(χ^2=7.923,P<0.05)。发生淋巴结转移的结肠癌病例的癌组织和淋巴结中Flotillin-1的表达与未发生淋巴结转移的结肠癌病例有显著差(经Fisher确切概率法分析,差异有统计学意义(P<0.05)。结论 Flotillin-1在结肠癌组织中的表达与淋巴道转移具有相关性。

Objective To explore the expression of Flotillin-1 in colorectal cancer. Methods From December 2014 to June 2017 Thirty-four cases of colorectal cancer and fourteen cases of non-colon cancer confirmed by pathology from 2014 to 2017 were selected. The expression of Flotillin-1 protein in pathological tissues and lymph nodes was detected and compared by immunohistochemical method. Results The positive rate of Flotillin-1 in colorectal cancer was 58.8%,which was significantly higher than that in non-colon cancer group 14.3%(χ^2=7.923,P <0.05). The expression of Flotillin-1 in the tissues and lymph nodes of the colorectal cancer with lymph node metastasis was significantly different from that of the colorectal cancer without lymph node metastasis(detected by Fisher exact probability method(P<0.05). Conclusion The expression of Flotillin-1 in colorectal cancer is correlated with lymphatic metastasis.