制霉菌素与甲硝唑联合乳酸菌阴道胶囊治疗滴虫性阴道炎的效果评价

Evaluation of the Effect of Nystatin and Metronidazole Combined with Lactic Acid Bacteria Vaginal Capsule on Trichomonas Vaginitis

目的探索制霉菌素与甲硝唑联合乳酸菌阴道胶囊治疗滴虫性阴道炎的效果。方法选择该院就诊的滴虫性阴道炎患者作为探究对象(例数:100例;时间:2017年11月-2018年10月),实施信封随机分组模式进行分组,50例/组,分别给予甲硝唑、制霉菌素与甲硝唑联合乳酸菌阴道胶囊治疗,比较2组临床疗效、临床症状改善情况、炎症因子相关指标、不良反应发生情况。结果观察组治疗效果为98.00%,高于对照组(χ^2=9.469 7、P=0.002 1);外阴瘙痒(47例)、白带增多(44例)、白带臭味(45例)、黄色白带(46例)改善情况优于对照组(χ^2=16.318 5、P=0.000 1;χ^2=11.415 5、P=0.000 7;χ^2=6.250 0、P=0.012 4;χ^2=4.761 9、P=0.029 1);治疗后TNF-α(31.54±5.32)ng/L、IL-6(6.31±0.54)pg/mL、IL-8(1.25±0.32)pg/mL优于对照组(t=5.551 3、13.791 8、20.002 5、P<0.05);不良反应发生例数与对照组相比无差异性(χ^2=1.041 7、P=0.307 4)。结论制霉菌素与甲硝唑联合乳酸菌阴道胶囊治疗滴虫性阴道炎疗效较为确切,可推广。

Objective To explore the effect of nystatin combined with metronidazole in the treatment of trichomonas vaginitis. Methods The patients with trichomonas vaginitis who were treated in our hospital were selected as the subjects of investigation(number of cases: 100 cases;time: November 2017 to October 2018). Envelope random grouping mode was implemented for grouping, 50 cases each group. Metronidazole combined with lactic acid bacteria vaginal capsules, nystatin and Metronidazole combined with lactic acid bacteria vaginal capsules were given to the two groups respectively. The clinical efficacy, clinical symptoms, inflammatory factors related indicators, adverse reactions occurred in the two groups were compared. Results The therapeutic effect of the observation group was 98.00%, which was higher than that of the control group(χ^2=9.469 7, P =0.002 1). In the observation group, 47 cases had genital itching, 44 cases had vaginal discharge increased, 45 cases had leucorrhea odor, 46 cases had yellow leucorrhea. The improvement was better than that in the control group(t=16.318 5, P=0.000 1,t=11.415 5,P=0.000 1;t=6.2500,P=0.012 4,t=4.761 9, P=0.029 1). After treatment, Post-TNF-α in the observation group was(31.54±5.32)ng/L, IL-6 was(6.31±0.54)pg/mL, IL-8 was(1.25±0.32)pg/mL, which were superior to the control group(t=5.5513, 13.791 8, 20.002 5, P<0.05). The difference of the rate of adverse reactions between the two groups was not statistically significant(χ^2=1.041 7,P=0.307 4). Conclusion Nystatin and metronidazole combined with lactic acid bacteria vaginal capsules is effective in the treatment of trichomonas vaginitis, which is worthy of promotion.