利培酮联合银杏叶胶囊对老年精神分裂症患者神经功能的影响

Effect of risperidone combined with ginkgo biloba capsule on neurological function in elderly patients with schizophrenia

目的探讨利培酮联合银杏叶胶囊对老年精神分裂症患者神经功能的影响,为老年精神分裂症的治疗提供依据。方法选择2017年1月至2018年3月杭州市第七人民医院收治的94例老年精神分裂症患者作为研究对象。按照随机数字表法分为联合组和对照组,每组47例。对照组采用利培酮治疗。联合组在对照组基础上,给予银杏叶胶囊治疗。两组患者均连续治疗3个月。检测两组患者治疗前后血清脑源性神经营养因子(BDNF)、同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平。采用阴性症状和阳性症状量表(PANSS)评估两组患者症状的严重程度。采用威斯康星卡片分类测试(WCST)评估两组患者的认知功能。采用生活质量综合评定问卷(GQOLI-74)评估两组患者的生存质量。记录两组患者治疗中不良反应的发生情况。用SPSS21.0软件进行数据的统计处理,计数资料的组间比较用χ^2检验,计量资料的组内比较用配对t检验,组间比较用独立样本t检验。结果联合组总有效率为89.36%,明显高于对照组(72.34%),差异有统计学意义(P<0.05)。两组患者治疗后BDNF水平明显升高,Hcy、NSE和MBP水平明显降低,治疗后联合组BDNF水平明显高于对照组,Hcy、NSE和MBP水平明显低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后PANSS评分、WCST评分明显降低,GQOLI-74评分明显升高;治疗后联合组PANSS评分、WCST评分均明显低于对照组,GQOLI-74评分明显高于对照组,差异均有统计学意义(P<0.05)。联合组不良反应发生率为23.40%,对照组为19.15%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论利培酮联合银杏叶胶囊治疗老年精神分裂症的疗效确切,可改善患者的神经功能。

Objective To investigate the effect of risperidone combined with ginkgo biloba capsule on neurological function in elderly schizophrenic patients,and to provide the basis for treating elderly schizophrenic patients. Methods From January of 2017 to March of 2018,94 elderly schizophrenic patients in Hangzhou Seventh People's Hospital were selected as the subjects. The subjects were randomly divided into the study (combined treatment of risperidone with ginkgo biloba capsule,47 cases) group and control (risperidone,47 cases) group. The treatment duration was 3 months. The serum levels of BDNF,Hcy,NSE and MBP were measured before and after treatment. PANSS scale was used to assess the severity of schizophrenia in two groups. The Wisconsin Card Sorting Test (WCST) was used to assess the cognitive function of the two groups. The life quality of the two groups was assessed by the comprehensive quality of life questionnaire (GQOLI-74). The adverse reactions of the two groups were recorded. The χ^2 test and t test were used to analyze the data. The used software was SPSS 21.0. Results The total effective rate (89.36%) of the study group was significantly higher than that (72.34%) of the control group,P<0.05. After treatment,the BDNF levels of the two groups increased significantly,Hcy,NSE and MBP levels decreased significantly (P<0.05);the BDNF level of the study group was significantly higher than that of the control group,while Hcy,NSE and MBP levels of study group were significantly lower than those of the control group (P <0.05). After treatment,the PANSS scores and WCST scores of the two groups decreased significantly,the GQOLI-74 scores increased significantly (P<0.05);the PANSS score and WCST score of the study group were significantly lower than those of the control group,the GQOLI-74 score of the study group was significantly higher than that of the control group (P <0.05). The adverse reaction rates of the study group and the control group were 23.40% and 19.15%, respectively;no difference was found (P>0.05). Conclusion Risperidone combined with Ginkgo biloba capsule was effective for treating the senile schizophrenia and could effectively improve the neurological function of patients.