联合抗苗勒氏管激素、卵泡刺激素、雌二醇检测在诊断卵巢早衰中的应用价值分析

Combined application of AMH, FSH and E2 in the diagnosis of premature ovarian failure

目的探讨联合抗苗勒氏管激素(AMH)、卵泡刺激素(FSH)、雌二醇(E2)检测在诊断卵巢早衰中的应用价值。方法选取2017年4月-2018年4月于本院治疗的120例不孕妇女患者为研究对象,根据获取卵泡的数目将患者分为卵巢正常组和卵巢早衰组,对比2组的AMH、FSH、E2水平,采用受试者工作特征(ROC)分析AMH、FSH、E2和联合预测的曲线下面积(AUC)和灵敏度、特异度。结果卵巢正常组FSH、E2水平均显著高于卵巢早衰组(P<0.05),其AMH水平显著低于卵巢早衰组(P<0.05);联合检测的ROC面积和灵敏度均高于AMH、FSH、E2(P<0.01)。结论联合AMH、FSH、E2检测在诊断卵巢早衰中的参考价值较高,值得临床推广应用。

Objective To explore the value of combined detection of AMH, FSH and E2 in the diagnosis of premature ovarian failure. Methods A total of 120 infertile women in our hospital from April 2017 to April 2018 were selected. According to the number of acquired follicles, the patients were divided into normal ovarian group and premature ovarian failure group. The AMH, FSH and E2 were compared. The area under the curve(AUC) and sensitivity and specificity were calculated and analyzed using receiver operating characteristic(ROC) curves for AMH, FSH, and E2. Results The levels of FSH and E2 in the normal ovarian tissue were significantly higher than those in the premature ovarian failure group(P<0.05). The AMH level was significantly lower in the ovarian normal ovarian failure group(P<0.05). The ROC area, specificity and sensitivity of the combined detection were higher than AMH, FSH, E2(P<0.01). Conclusion Combined detection of AMH, FSH, and E2 has higher reference value in the diagnosis of premature ovarian failure and is worthy of clinical application.