摘要
目的改进国家药品标准中单磷酸阿糖腺苷水分测定的方法。方法以10%咪唑无水甲醇为溶剂,采用容量滴定法,用水分测定仪滴定费休氏试液至终点。结果3~15 mg含水量与消耗滴定液的体积呈良好的线性关系(r=0.9971),平均回收率为98.6%(n=9)。结论所用方法稳定、准确、可靠,可用于单磷酸阿糖腺苷的水分测定。
OBJECTIVE To improve the method for the determination of water content of Vidarabine monophosphate in National Drug Standard.METHODS The solvent was 10%imidazole methanol anhydrous.Titrate Karl Fischer reagent to the end point with a moisture analyze by Volumetic titration.RESULTS The linearity was obtained over 1-15 mg of purified water(r=0.9971).The average recovery of the method was 98.6%(n=5).CONCLUSION This method is simple and rapid.It can be used for the water determination of Vidarabine monophosphare.
作者
梁改玲
李洁
全巧玲
LIANG Gailing;LI Jie;QUAN Qiaoling(Henan Provincial Institute of Food and Drug Control,Zhengzhou,Henan,450018 P.R.China;Hami Institute of Food and Drug Control,Hami,Xinjiang,839000 P.R.China)
出处
《华西药学杂志》
CAS
CSCD
2019年第3期291-293,共3页
West China Journal of Pharmaceutical Sciences
关键词
单磷酸阿糖腺苷
费休氏法
费休氏试液
咪唑
无水甲醇
水分测定仪
容量滴定法
质量控制
Vidarabine monophosphare
Karl Fischer reagent
Karl Fischer's method
Imidazole
Water determination apparatus
Volumetric titration
Quality control
