泻火平突散治疗急性期甲状腺相关眼病

Treatment of Acute Thyroid Associated Ophthalmopathy with Xiehuo Pingtu Powder

目的:观察泻火平突散治疗急性期甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)的临床疗效。方法:将66例急性期TAO患者按随机数字表法分为对照组和观察组各33例。对照组给予综合治疗,观察组在对照组治疗基础上给予泻火平突散。两组疗程均为12周。比较两组患者眼部主要症状、中医证候积分、临床活动度评分(clinical activity score,CAS)、软组织炎症分级(NOSPECS)的变化。结果:①临床疗效:对照组有效率为63.64%,观察组有效率为81.82%,两组比较,差异有统计学意义(P<0.05)。②中医症状积分:两组患者治疗后积分均下降,观察组治疗后低于同期对照组,差异均有统计学意义(P<0.05)。③NOSPECS分级:两组患者治疗后分级均显著下降,观察组分级下降更为明显,差异均有统计学意义(P<0.05)。④CAS评分:两组患者治疗后积分均下降,观察组治疗后低于同期对照组,差异均有统计学意义(P<0.05)。结论:泻火平突散治疗急性期TAO疗效显著,可降低患者中医症状积分、CAS评分及NOSPECS分级。

Objective:To observe the clinical efficacy of Xiehuo Pingtu Powder in treatment of acute thyroid-associated ophthalmopathy(TAO).Methods:Sixty-six patients with acute phase TAO were randomly divided into control group and observation group,33 cases each.The control group was given comprehensive treatment,and the observation group was given the diarrhea level on the basis of the treatment of the control group.Both groups were treated for 12 weeks.The main symptoms of the eye,TCM syndrome scores,clinical activity score(CAS),and soft tissue inflammation grade(NOSPECS)were compared between the two groups.Results:①Clinical efficacy:The effective rate of the control group was 63.64%,and the effective rate of the observation group was 81.82%.The difference between the two groups was statistically significant(P<0.05).②TCM syndrome scores:The scores of the two groups of patients decreased after treatment,and the observation group was lower than the control group after treatment,the difference was statistically significant(P<0.05).③NOSPECS classification:The scores of the two groups were significantly decreased after treatment,and the decrease of the component level was more obvious,and the difference was statistically significant(P<0.05).④CAS score:The scores of the two groups were decreased after treatment.The observation group was lower than the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion:Xiehuo Pingtu Powder has a significant effect on the treatment of acute phase TAO,which can reduce the TCM syndrome score,CAS score and NOSPECS classification.