25490例儿童手足口病血清CoxA16-IgM和EV71-IgM检测结果分析

Result Analysis of Serum CoxA16-IgM and EV71-IgM in 25490 Children with Hand,Foot and Mouth Disease

目的回顾性分析儿童手足口病血清CoxA16-IgM和EV71-IgM表达情况。方法选取经清远市妇幼保健院确诊的儿童手足口病25 490例,对所有患儿均进行血清CoxA16-IgM和EV71-IgM检测,对检测结果进行统计分析。结果25 490例患儿共检出血清CoxA16-IgM阳性1715例(6.73%),血清EV71-IgM阳性3617例(14.19%),血清CoxA16-IgM和血清EV71-IgM双阳性182例(0.71%)。血清CoxA16-IgM阳性率和血清EV71-IgM阳性率差异有统计学意义(χ^2=757.72,P<0.05)。男性患儿抗体阳性率为30.15%,女性患儿的抗体阳性率为11.60%,男性患儿与女性患儿抗体阳性率差异有统计学意义(χ^2=1 325.91,P<0.05).CoxA16-IgM和EV71-IgM均在2~3岁组阳性率最高。结论小儿手足口病以柯萨奇病毒A16型和EV-71型感染最为常见,尤其是2~3岁年龄段,是手足口病高发阶段。

Objective To retrospectively analyze the levels of serum CoxA16-IgM and EV71-IgM in children with hand,foot and mouth disease.Methods A total of 25 490 children with hand,foot and mouth disease diagnosed in our hospital were selected.Serum CoxA16-IgM and EV71-IgM were examined and analyzed in all children.Results A total of 1 715 cases(6.73%)were positive for CoxA16-IgM,3 617 cases(14.19%)were positive for EV71-IgM,and 182 cases(0.71%)were double positive for CoxA16-IgM and EV71-IgM.There was significant difference between the positive rates of CoxA16-IgM and EV71-IgM(χ^2=757.72,P<0.05).The positive rate of antibody in male and female children was significantly different,30.15%of male and 11.60%of female,respectively(χ^2=1325.91,P<0.05).The positive rates of CoxA16-IgM and EV71-IgM were the highest in 2~3 years old group.Conclusion Coxsackievirus A16 and EV-71 are the most common types of hand,foot and mouth disease in children,especially in the age group of 2.3 years,which is the high incidence stage of hand,foot and mouth disease.