盐酸米诺环素软膏联合甲硝唑药膜对牙周病的牙周指数抗炎因子的影响研究

Effects of Minocycline Lydrochloride Ointment combined with Metronidazole Film on Periodontal Index and Anti-inflammatory Factors in Patients with Periodontal Disease

目的:通过对抗炎因子以及牙周指数等进行相应研究,评估牙周病患者的治疗中运用盐酸米诺环素软膏联合甲硝唑药膜的效果。方法:84例牙周病患者按随机数字法随机分为对照组和治疗组。对照组将甲硝唑膜(含0.2560g甲硝唑和0.1024g醋酸氯己定)每周2次置入牙周袋内,治疗组在对照组的基础上,将米诺环素软膏(含10mg盐酸米诺环素),注满牙周袋,每周2次。两组均治疗4周。比较两组临床指标、总有效率及不良反应。结果:治疗前两组菌斑指数(PLI)、牙周袋探查深度(PD)、龈沟出血指数(SBI)无显著性差异(P>0.05);与对照组比较,治疗组的菌斑指数、牙周袋探诊深度、及龈沟出血指数较对照组显著减少(P<0.05)。与对照组的总效率相比,治疗组明显较高(92.86%VS71.43%,P<0.05)。两组均无明显不良反应发生。结论:在对于牙周病患者的治疗中,运用盐酸米诺环素软膏联合甲硝唑膜有着非常明显的作用,其不仅能够使得牙周指数、抗炎因子有效改善,同时也确保了安全性和有效性。

Objective: To evaluate the efficacy of minocycline hydrochloride ointment combined with metronidazole film in the treatment of periodontal disease by studying anti-inflammatory factors and periodontal index. Methods: 84 patients with periodontal disease were randomly divided into control group and treatment group. The control group was given metronidazole film (containing 0.2560g metronidazole and 0.1024g chlorhexidine acetate) into periodontal pocket twice a week. The treatment group was given minocycline ointment (containing 10mg minocycline hydrochloride) twice a week on the basis of the control group. Both groups were treated for 4 weeks. The clinical indicators, total effective rate and adverse reactions were compared between the two groups. Results: There was no significant difference in plaque index (PLI), periodontal bag exploration depth (PD) and gingival sulcus bleeding index (SBI) between the two groups before treatment (P>0.05);compared with the control group, the plaque index, periodontal bag exploration depth and gingival sulcus bleeding index in the treatment group were significantly lower than those in the control group (P<0.05). Compared with the total efficiency of the control group, the treatment group was significantly higher (92.86% VS 71.43%, P<0.05). There were no obvious adverse reactions in both groups. Conclusion: Minocycline hydrochloride ointment combined with metronidazole film has a very obvious effect in the treatment of periodontal disease. It can not only effectively improve periodontal index and anti-inflammatory factors, but also ensure the safety and effectiveness.