实时三维超声诊断肝硬化患者左心功能、门静脉血流动力学与肝功能严重程度的相关性分析

Correlation analysis of real-time three-dimensional ultrasound in diagnosis of left ventricular function,portal hemodynamics and severity of liver function in patients with liver cirrhosis

目的:分析实时三维超声诊断肝硬化患者左心功能、门静脉血流动力学与肝功能严重程度的相关性。方法:将本院2017年1月~2018年12月收治的90例肝硬化患者作为肝硬化组,并依照患者Child-Pauh分级标准将肝硬化组分为A组、B组及C组,同期选择90例行健康体检的健康者作为对照组;对患者行实时三维超声检查,检查左心功能、门静脉血流动力学参数;采用Pearson相关性分析左心功能、门静脉血流动力学与肝功能严重程度关系。结果:肝硬化组患者左心E及E/A水平显著低于对照组(P<0.05),A水平显著高于对照组(P<0.05);肝硬化组患者Dpv、Q水平明显高于健康对照组,差异有统计学意义(P<0.05),Vpv水平显著低于健康对照组(P<0.05);不同Child-Paugh级别患者E、A及E/A水平差异有统计学意义(P<0.05);不同Child-Paugh分级组患者门静脉血流动力学Dpv、Vpv及Q水平存明显差异,且差异有统计学意义(P<0.05);左心功能E与E/A与肝功能严重程度呈显著负相关关系(P<0.05),左心功能A与肝功能严重程度呈显著正相关关系(P<0.05),门静脉血流动力学Dpv、Vpv及QE与与肝功能严重程度呈显著正相关关系(P<0.05)。结论:采用实时三维超声可有效检测肝硬化患者左心功能指标及门静脉血流动力学指标变化情况,且左心功能、门静脉血流动力学与肝功能严重程度呈显著性相关关系。

Objective: To analyze the correlation between real-time three-dimensional ultrasound in diagnosis of left ventricular function, portal hemodynamics and severity of liver function in patients with liver cirrhosis. Methods: 90 patients with cirrhosis admitted to our hospital from January 2017 to December 2018 were enrolled in the cirrhosis group, and the cirrhosis components were group A, B and C according to the Child-Pauh classification criteria. During the same period, 90 healthy subjects who underwent physical examination were selected as the control group;real-time three-dimensional ultrasonography was performed to examine left ventricular function and portal hemodynamic parameters;Pearson correlation was used to analyze left ventricular function, portal hemodynamics and liver. Functional severity relationship. Results: The left heart E and E/A levels in the cirrhosis group were significantly lower than those in the control group ( P <0.05), and the A level was significantly higher than the control group ( P <0.05). The Dpv and Q levels in the cirrhosis group were significantly higher than those in the healthy control group. The difference was statistically significant ( P <0.05), and the level of V pv was significantly lower than that of healthy controls ( P <0.05). There were significant differences in E, A and E/A levels between different Child-Paugh patients ( P <0.05). There were significant differences in portal hemodynamics Dpv, Vpv and Q between the different Child-Paugh grades, and the difference was statistically significant ( P <0.05);left heart function E and E/A and liver function severity There was a significant negative correlation ( P <0.05). There was a significant positive correlation between left cardiac function A and liver function severity ( P <0.05). Portal vein hemodynamics Dpv, Vpv and QE were significantly associated with liver function severity. Positive correlation ( P <0.05). Conclusions: Real-time three-dimensional ultrasound can effectively detect left ventricular function and portal hemodynamics changes in patients with cirrhosis, and left heart function, portal hemodynamics and liver function severity are significantly correlated.