血必净注射液对重度烧伤患者发生脓毒症的预防作用及对炎性因子的影响

Preventive Effect of Xuebijing Injection on Sepsis in Patients with Severe Burn and Its Effect on Inflammatory Factors

目的:探讨血必净注射液对重度烧伤患者发生脓毒症的预防作用及对炎性因子的影响。方法:选取本院2015年7月至2017年12月收治的84例重度烧伤患者,通过简单随机分组分为观察组与对照组,各42例。入院后两组均予以常规烧伤治疗,包括:营养支持、器官保护、液体复苏、抗生素抗感染,并予以常规创面清创及换药。观察组在此基础上应用血必净注射液:50mL/次,2次/d,连续1周。比较两组脓毒症发生率、入院时、治疗1周的血清肌酐(Cr)、尿素氮(BUN)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、急性生理与慢性健康(APACHE)评分、序贯器官衰竭评分。结果:观察组脓毒症发生率为11.90%(5/42),对照组为30.95%(13/42),差异有统计学意义(P<0.05)。两组入院时的血清TNF-α、IL-6、Cr、BUN水平、APACHE评分、SOFA评分的差异无统计学意义(P>0.05)。治疗1周后,两组的血清TNF-α、IL-6、Cr、BUN水平、APACHE评分、SOFA评分均较入院时降低,差异有统计学意义(P<0.05)。观察组治疗1周后的血清TNF-α、IL-6、Cr、BUN水平、APACHE评分、SOFA评分低于对照组,差异有统计学意义(P<0.05)。结论:在西医常规治疗基础上应用血必净注射液治疗重度烧伤,可有效改善患者整体生理状况,抑制炎症因子,阻滞炎性递质诱导的炎性损伤,保护肾脏功能,预防脓毒症的发生,效果显著,值得推广。

Objective: To explore the preventive effect of Xuebijing injection on sepsis in severely burned patients and its effect on inflammatory factors. Methods: A total of 84 patients with severe burns admitted to our hospital from July 2015 to December 2017 were divided into observation group and control group by simple random grouping, with 42 cases in each group. After admission, both groups were treated with conventional burns, including: nutritional support, organ protection, fluid resuscitation, antibiotics, and conventional wound debridement and dressing change. On the basis of this, the observation group applied Xuebijing injection: 50 ml/time, twice/d for 1 week. The incidence of sepsis, serum levels of creatinine (Cr), urea nitrogen (BUN), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), acute physiology and chronic health (APACHE) score, sequential organ failure score (SOFA) at the time of admission and 1 week of treatmentwere compared between the two groups. Results: The incidence of sepsis in the observation group was 11.90%(5/42), and 30.95%(13/42) in the control group, the difference was statistically significant (P<0.05). There were no significant differences in serum levels of TNF-α, IL-6, Cr, BUN, APACHE scores, and SOFA scores between the two groups (P>0.05). After 1 week of treatment, the serum levels of TNF-α, IL-6, Cr, BUN, APACHE and SOFA were significantly lower than those at admission in both group (P<0.05). The serumlevels of TNF-α, IL-6, Cr, BUN, APACHEscore and SOFA scoreat 1 week of treatmentin the observation group were significantly lower than those in the control group(P<0.05). Conclusion: On the basis of routine treatment of western medicine, Xuebijing injection can treat severe burns, which can effectively improve the overall physiological condition of patients, inhibit inflammatory factors, block inflammatory damage induced by inflammatory transmitters, protect kidney function and prevent the occurrence of sepsis, the effect is significant, it is worth promoting.